Abstract
The previous 20 years of basic research on aging has identified a large number of genes and gene products whose expression can be manipulated in a variety of ways to increase the healthy life span of animal models such as yeast, nematodes, fruit flies, and mice. In an overt attempt to capitalize on this information, the National Institute on Aging (NIA) began a program in 2003 to identify nutritional and pharmaceutical interventions that could be safely employed to extend the healthy life span of mice. This program is called the Intervention Testing Program (ITP), and this article briefly describes the development of this initiative and some of the early success achieved during its first 10 years (2004-2014) of operation.
References
Jul 25, 2000·Mechanisms of Ageing and Development·H R WarnerA G Richardson
Jul 8, 2003·Science of Aging Knowledge Environment : SAGE KE·Huber R Warner
Jan 19, 2006·Genes & Development·R Wilson PowersStanley Fields
Jun 21, 2007·Aging Cell·Richard A MillerRandy Strong
Jul 18, 2008·Aging Cell·Randy StrongDavid E Harrison
Jul 10, 2009·Nature·David E HarrisonRichard A Miller
Jul 17, 2009·Nature·Matt Kaeberlein, Brian K Kennedy
Jan 20, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zelton Dave Sharp, Randy Strong
Apr 23, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Felipe Sierra
Oct 27, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Richard A MillerRandy Strong
Mar 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Randy StrongDavid E Harrison
May 17, 2012·Aging Cell·John E WilkinsonRichard A Miller
Nov 16, 2013·Science·Mitch Leslie
Nov 20, 2013·Aging Cell·David E HarrisonRichard A Miller
Nov 28, 2013·Cancer Prevention Research·Paul HastyZelton Dave Sharp
Dec 18, 2013·Aging Cell·Richard A MillerRandy Strong
Oct 31, 2014·Nature·Erika Check Hayden
Dec 30, 2014·Science Translational Medicine·Joan B MannickLloyd B Klickstein
Citations
Mar 16, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Luigi FerrucciDiana Kuh
Aug 16, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·William R Swindell
Feb 22, 2017·Nature Communications·Mark LucanicPatrick C Phillips
Dec 8, 2015·Biochimica Et Biophysica Acta·Veronica Galvan, Matthew J Hart
Jun 3, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kathleen E Fischer, Nicole C Riddle
Jun 24, 2017·PloS One·Jonathan D ProtoJohnny Huard
Mar 7, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gary A FordDavid G Le Couteur
Jan 3, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christy S CarterSteven Austad
Sep 12, 2018·Nutrients·Nobuaki OkumuraTakahiko Shimizu
Sep 11, 2016·Aging Cell·Loic VerlingueArturo Londoño-Vallejo
Aug 15, 2016·AIMS Public Health·Linna Tam-SetoShilpa Dogra
Aug 26, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arlan Richardson
Jan 19, 2021·Pituitary·Silvana Duran-OrtizJohn J Kopchick
Feb 29, 2020·Ageing Research Reviews·Marta Gonzalez-FreireRafael de Cabo