Jan 1, 1985

Nicardipine for stable angina pectoris

British Journal of Clinical Pharmacology
S ScheidtD Freedman


Nicardipine, 30 and 40 mg thrice daily, was administered to 66 patients with stable angina pectoris in a multicentre, randomised, double-blind, cross-over trial. With nicardipine therapy, duration of exercise and cumulative oxygen consumption increased, while times to onset of angina and 1 mm ST segment depression were prolonged. Anginal frequency and nitroglycerin consumption declined with use of nicardipine, but this did not reach statistical significance. Resting heart rate increased slightly and resting blood pressure decreased. Two patients on nicardipine and one on placebo sustained acute infarction. Otherwise, side effects were generally mild and transient.

  • References19
  • Citations9


Mentioned in this Paper

Diastolic Blood Pressure
Cross-Over Studies
Cardiopulmonary Exercise Test
Angina Pectoris
Blood Pressure
Acute Infarct
Interphase Cell

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.