Niche-dependent tumorigenic capacity of malignant ovarian ascites-derived cancer cell subpopulations

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Ehood KatzMaty Tzukerman

Abstract

In previous studies, we have used human embryonic stem cells (hESC) to generate a tissue microenvironment in immunocompromised mice as an experimental approach for studying human tumorigenesis. We now examine the attributes of such a cellular microenvironment in supporting the growth of human cancer cells freshly harvested from malignant ovarian ascites and to determine whether there are differences among subsets of ascites-derived cancer cells in terms of tumorigenic capacity in the conventional murine xenograft model and in the hESC-derived microenvironment. Freshly harvested malignant ovarian ascites-derived cancer cells and six derivative ovarian cancer cell subpopulations (CCSP) were characterized for ovarian cancer-associated biomarker expression both in vitro and in vivo and for their capacity to generate tumors in the two models. Ovarian cancer-associated biomarkers were detected in the ascites-derived cancer cells and in the six newly established CCSPs. Nevertheless, certain CCSPs that did not develop into tumors in a conventional murine xenograft model did generate tumors in the hESC-derived cellular microenvironment, indicating variable niche dependency for the tumorigenic capacity of the different CCSPs. The hESC-de...Continue Reading

References

Mar 1, 1990·Journal of Clinical Pathology·U LatzaH Stein
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Nov 2, 2001·Nature·T ReyaI L Weissman
Jan 5, 2002·Cancer Treatment and Research·Robert C BastGordon Mills
May 4, 2002·Molecular and Cellular Endocrinology·Ben DavidsonReuven Reich
Aug 10, 2002·Seminars in Oncology·Dirk Schrijvers, Jan B Vermorken
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jun 5, 2003·Nature Reviews. Cancer·Raghu Kalluri
Oct 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·Maty TzukermanKarl Skorecki
Jan 17, 2004·Cancer Biology & Therapy·Judah Folkman
Jan 23, 2004·Nature Reviews. Cancer·Annapoorni Rangarajan, Robert A Weinberg
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Charlotte KuperwasserRobert A Weinberg
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
May 3, 2005·Nature Reviews. Cancer·Honami Naora, Denise J Montell
May 17, 2005·Cancer Cell·Karin E de VisserLisa M Coussens
Mar 22, 2006·Pediatric Research·Wei GuoHong Wu
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Jun 22, 2006·Seminars in Cancer Biology·S A Bapat
Aug 2, 2006·Cell Cycle·Akira Orimo, Robert A Weinberg
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Max S Wicha
Oct 7, 2006·Virchows Archiv : an International Journal of Pathology·Sivan ElloulReuven Reich
Nov 30, 2006·Current Opinion in Oncology·Muhammad Al-Hajj
Mar 17, 2007·Current Problems in Cancer·Shian-Ying SungPeter A S Johnstone
Jul 5, 2007·Differentiation; Research in Biological Diversity·Colleen WuCalvin D Roskelley
Jul 21, 2007·Science·Priscilla N KellyAndreas Strasser
Feb 15, 2008·The Journal of Biological Chemistry·Jiwang Zhang, Linheng Li
Mar 15, 2008·The Journal of Clinical Investigation·Hilary A KennyErnst Lengyel

❮ Previous
Next ❯

Citations

Dec 4, 2012·Cancer Letters·Delphine Tamara Marie-EgyptienneRichard Peter Hill
Jan 28, 2014·Biochemistry. Biokhimii︠a︡·T S GerashchenkoN V Cherdyntseva
Mar 20, 2013·BioMed Research International·Qinglei ZhanSaiming Ngai
Jun 28, 2014·Advanced Drug Delivery Reviews·Daniela LoessnerJudith Ann Clements
Apr 8, 2010·Seminars in Cancer Biology·Patrick C HermannChristopher Heeschen
Aug 21, 2010·International Journal of Cancer. Journal International Du Cancer·Raphael LisArash Rafii
Oct 15, 2013·International Journal of Cancer. Journal International Du Cancer·Seema JamilLars Ährlund-Richter
Aug 29, 2012·ISRN Oncology·M H CruzJ S Yakisich
Aug 3, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Sharmila A BapatKenneth P Nephew
Aug 26, 2014·Seminars in Cancer Biology·Isabell HultmanLars Ahrlund-Richter
Dec 8, 2019·Journal of Ovarian Research·Vahideh KeyvaniMohammad Reza Abbaszadegan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.