Niches for hematopoietic stem cells and immune cell progenitors

International Immunology
Tatsuki SugiyamaTakashi Nagasawa

Abstract

The special microenvironments, termed niches, with which hematopoietic stem cells (HSCs) are in contact, have been thought to be required for the maintenance of HSCs and the generation of immune cells in bone marrow. Although the identity of the HSC niche has been a subject of long-standing debate, recent findings demonstrate that a population of mesenchymal stem cells, termed CXC chemokine ligand (CXCL)12-abundant reticular (CAR) cells or leptin receptor-expressing (LepR+) cells, are the major cellular components of niches for HSCs and lymphoid progenitors, which express specific transcription factors, including Foxc1 and Ebf3, and cytokines, including CXCL12 and stem cell factor (SCF), essential for their niche functions. The identity and functions of other types of cells, including osteoblasts, sinusoidal endothelial cells, periarteriolar cells, megakaryocytes and a population of macrophages in HSC maintenance, have also been shown.

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Citations

Oct 6, 2020·Frontiers in Immunology·Roberto ToniAnna Tampieri
Sep 24, 2020·Oxidative Medicine and Cellular Longevity·Lan ZhaoShaoheng Zhang
Dec 4, 2020·European Journal of Haematology·Johanna C Purdy, Joseph J Shatzel
Feb 3, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alexander VespreyUgur M Ayturk
Aug 4, 2021·Science China. Life Sciences·Shiru YuanTao Cheng
Aug 17, 2021·The Bulletin of Tokyo Dental College·Sumiharu MoritaAkira Yamaguchi

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