PMID: 1195022Dec 1, 1975Paper

Nickel deficiency and nickel-rhodium interaction in chicks

The Journal of Nutrition
Forrest H NielsenD A Ollerich

Abstract

Nickel deficiency was produced in chicks under near optimal growth conditions. This judgment is based on the finding that chicks fed the experimental diet supplemented with nickel had a very satisfactory growth rate, over 600 g in 4 weeks. To induce nickel deficiency, chicks were raised in plastic cages located inside plastic isolators and were fed diets (containing 2-15 ng of nickel/g) based on dried skim milk, acid-washed ground corn, EDTA-extracted soy protein, and corn oil. In 2 experiments, controls were fed 3 mug of nickel/g as NiCl2-6H2O. In experiment 3, instead of 1 control group 25, 50, 250, and 2,500 ng/g of supplemental dietary nickel as NiCl2-6H2O were each given to separate groups of chicks. Nickel deprivation resulted in: ultrastructural changes in the liver with the most obvious abnormality in the organization of the rough endoplasmic reticulum; altered gross appearance, reduced oxidative ability, and decreased lipid phosphorus in the liver; altered shank skin pigmentation that was associated with a decrease in yellow lipochrome pigments; and lower hematocrits. Deficiency also tended to increase the thickness of the legs and size of the hock; decrease the length:width ratios of the tibias and femurs; and decreas...Continue Reading

Citations

Mar 1, 1991·Biological Trace Element Research·M HegstedP Wozniak
Aug 1, 1988·Biological Trace Element Research·M O Theisen, C Blincoe
Jun 26, 1999·Journal of Toxicology. Clinical Toxicology·D G Barceloux
Apr 1, 1984·Nutrition Reviews
May 25, 2013·International Journal of Environmental Research and Public Health·Bangyuan WuJianying Huang
Sep 28, 2018·Biological Trace Element Research·Jerry W Spears
Sep 1, 1988·Biological Trace Element Research·F H NielsenE O Uthus
Dec 1, 1979·Biological Trace Element Research·F H Nielsen, T R Shuler
Aug 1, 1983·Biological Trace Element Research·F H NielsenW E Cornatzer
Dec 1, 1979·Biological Trace Element Research·F H NielsenE O Uthus
Jun 1, 1981·Biological Trace Element Research·F H Nielsen, T J Zimmerman
Jul 1, 1988·Biological Trace Element Research·E O Uthus, F H Nielsen
Sep 1, 1980·Biological Trace Element Research·F H Nielsen
Jan 1, 1987·Food Additives and Contaminants·G A Smart, J C Sherlock
Oct 1, 1984·Biological Trace Element Research·S R StarnesR W Harvey
May 1, 1982·Chemico-biological Interactions·M KnuuttilaH Olkkonen
Mar 22, 2005·Biochimica Et Biophysica Acta·Jacqueline KeyhaniNahid Einollahi
Feb 17, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Eric F PaneChris M Wood

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