PMID: 1195023Dec 1, 1975Paper

Nickel deficiency in rats

The Journal of Nutrition
F H NielsenD A Ollerich

Abstract

Nickel deficiency was produced in rats fed diet (containing 2-15 ng of mickel/g) based on dried skim mile, acid-washed ground corn, EDTA-extracted soy protein, and corn oil. Controls were fed a supplemental 3 mug of nickel/g of diet as NiCl2-6H2O. The rats were raised in plastic cages located inside laminar flow racks. Nickel deprivation resulted in several consistent pathological findings. These included: (1) increased perinatal mortality, (2) unthriftiness in young rats characterized by a rough coat and/or uneven hair development, (3) altered gross appearance (color) of the liver, (4) increased rate of alpha-glycerophosphate oxidation by liver homogenates, (5) decreased liver cholesterol, and (6) ultrastructural changes in the liver with the most obvious difference in the amount and organization of the rough endoplasmic reticulum. Nickel deficiency in rats tended to decrease growth, hematocrits, and liver total lipids and phospholipids.

Citations

Dec 1, 1979·Biological Trace Element Research·F H NielsenE O Uthus
Dec 31, 2014·Biological Trace Element Research·Kun TangShuang Yin
Jul 1, 1977·Journal of Dairy Science·J W SpearsE E Hatfield
Jan 1, 1989·Critical Reviews in Toxicology·T P CooganM Costa
Jan 1, 1980·Annals of the New York Academy of Sciences·F H NielsenE O Uthus
May 10, 2008·Biological Trace Element Research·Monika KatkoZsuzsa Varga
Sep 1, 1980·Biological Trace Element Research·F H Nielsen
Jul 1, 1988·Biological Trace Element Research·E O Uthus, F H Nielsen
Jun 26, 1999·Journal of Toxicology. Clinical Toxicology·D G Barceloux
Apr 1, 1984·Nutrition Reviews
Jan 1, 1987·Food Additives and Contaminants·G A Smart, J C Sherlock
Apr 9, 1998·Biological Trace Element Research·G I StanglM Kirchgessner
Oct 1, 1984·Biological Trace Element Research·S R StarnesR W Harvey
Oct 1, 1996·Reviews on Environmental Health·H Savolainen
Feb 1, 1997·Food Additives and Contaminants·G N Flint, S Packirisamy
Sep 1, 1988·Biological Trace Element Research·F H NielsenE O Uthus
Aug 1, 1988·Biological Trace Element Research·M O Theisen, C Blincoe
Nov 28, 2012·Biological Trace Element Research·Bangyuan WuJuan Liu
May 25, 2013·International Journal of Environmental Research and Public Health·Bangyuan WuJianying Huang
Dec 1, 1979·Biological Trace Element Research·F H Nielsen, T R Shuler
Feb 1, 1996·Biological Trace Element Research·K YokoiY Itokawa
Feb 22, 2001·Small Ruminant Research : the Journal of the International Goat Association·A A. Adeloye, M B. Yousouf
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Feb 17, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Eric F PaneChris M Wood
Aug 22, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Joanna PieczyńskaMartyna Sołtysik

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