Nickel hypersensitivity. Nickel binding to amino acids and lymphocytes

The British Journal of Dermatology
F HutchinsonE J Raffle

Abstract

The nature of a protein hapten conjugate which could effect lymphocyte transformation in nickel hypersensitivity was investigated by subjecting the culture media employed to radiochromatographic analysis. Autoradiographic studies with 63Ni demonstrate direct binding of nickel salts to the lymphocyte cell surface. This occurs with a proportion of lymphocytes both from nickel sensitive and from control subjects and so binding is not of itself the stimulus for transformation.

References

Jan 1, 1974·International Archives of Allergy and Applied Immunology·J M Jones, H E Amos
Oct 1, 1972·The British Journal of Dermatology·L Forman, S Alexander
Feb 1, 1973·The Journal of Investigative Dermatology·L E MillikanJ E Foote
Jun 1, 1972·The Journal of Investigative Dermatology·F HutchinsonT M Macleod
Jan 1, 1970·International Archives of Allergy and Applied Immunology·G A CaronT T Provost
Feb 1, 1970·British Journal of Haematology·R Harris, E O Ukaejiofo

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Citations

Jul 1, 1981·Mutation Research·A LéonardP Jacquet
Jun 9, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Marc Schmidt, Matthias Goebeler
Feb 1, 1995·Contact Dermatitis·D BasketterJ P Lepoittevin

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