Nickel induces oxidative burst, NF-κB activation and interleukin-8 production in human neutrophils.

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Marisa FreitasEduarda Fernandes

Abstract

Many lines of evidence have suggested that oxidative stress and inflammation play a pivotal role in the toxicity of nickel salts. Considering that neutrophils are active participants in inflammatory processes, namely by producing high amounts of reactive oxygen species, the aim of the present study was to evaluate the putative activation of human neutrophils' oxidative burst by nickel. Subsequently, the influence of nickel in the pathways leading to NADPH oxidation in neutrophils was evaluated by measuring protein kinase C (PKC) activation. The effects of nickel on neutrophils' nuclear factor κB (NF-κB) activation and on the production of the proinflammatory mediators interleukin (IL)-1β, IL-6, IL-8 and tumour necrosis factor α were also evaluated. The results obtained showed that nickel, at concentrations that may be attained in vivo, stimulates the production of superoxide radical (O(2)(·-)), hydrogen peroxide (H(2)O(2)), and hypochlorous acid (HOCl) in human neutrophils in vitro, via activation of PKC. In addition, nickel was shown to activate NF-κB and to induce the production of IL-8 in these cells. These observations indicate that the sustained activation of human neutrophils by nickel may contribute for the long-term adv...Continue Reading

References

Sep 1, 1994·Environmental Health Perspectives·M CostaZ Zhuang
Jul 1, 1997·American Journal of Respiratory Cell and Molecular Biology·T S Blackwell, J W Christman
Jul 11, 1998·Journal of Biomedical Materials Research·G CiapettiA Pizzoferrato
Oct 27, 1998·Journal of Biomedical Materials Research·M WagnerC J Kirkpatrick
Mar 23, 2000·The Biochemical Journal·L V DekkerA W Segal
May 16, 2000·Chest·J W ChristmanT S Blackwell
Aug 11, 2000·The American Journal of Medicine·B M Babior
Dec 29, 2000·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A V Kudrin
Jan 3, 2001·The Journal of Clinical Investigation·P P Tak, G S Firestein
Apr 9, 2001·The Journal of Biological Chemistry·C HuangX Shi
Mar 30, 2002·Critical Reviews in Oncology/hematology·E Denkhaus, K Salnikow
Mar 30, 2002·Critical Reviews in Oncology/hematology·Fei Chen, Xianglin Shi
Apr 24, 2002·Antioxidants & Redox Signaling·Anna Karlsson, Claes Dahlgren
Apr 24, 2002·Antioxidants & Redox Signaling·Steve D SwainMark T Quinn
Jul 12, 2002·Microscopy Research and Technique·Wolf D Splettstoesser, Peter Schuff-Werner
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Anna CargnoniRoberto Ferrari
Nov 12, 2002·Environmental Health Perspectives·Fei Chen, Xianglin Shi
Nov 12, 2002·Environmental Health Perspectives·Yi HuangChuanshu Huang
Nov 12, 2002·Environmental Health Perspectives·Adriana R Oller
Jan 11, 2003·Journal of Biomedical Materials Research. Part a·Jill B LewisJohn C Wataha
Jun 7, 2003·Toxicology and Applied Pharmacology·Chang-Yu ChenYu-Tyng Huang
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D CavalloS Iavicoli
Dec 4, 2003·Mutation Research·Kazimierz S KasprzakKonstantin Salnikow
Dec 19, 2003·Journal of Toxicology and Environmental Health. Part a·James M AntoniniJenny R Roberts
Feb 21, 2004·Advances in Immunology·Patrick P McDonald
Mar 12, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·John C WatahaSerge Bouillaguet
Jun 29, 2005·Journal of Biomedical Materials Research. Part a·J B LewisW-Y Tseng
Nov 12, 2005·Molecular and Cellular Biochemistry·Haitian LuChuanshu Huang
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
Jan 25, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sabine Hombach-KlonischThomas Klonisch
May 26, 2006·Biochemical Pharmacology·Geoffrey GloireJacques Piette
Jul 28, 2006·Mutagenesis·Ad M KnaapenFrederik J Van Schooten
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hiroaki NozawaDouglas Hanahan
Oct 20, 2006·International Journal of Hematology·Takayuki Kato, Seiichi Kitagawa
Dec 27, 2006·Free Radical Biology & Medicine·Lea FialkowGregory P Downey
Apr 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nejla GüngörAd M Knaapen
Jul 20, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nadège AdeMarc Pallardy
Jul 31, 2007·Future Microbiology·F BlasiV Valenti
Oct 24, 2007·The International Journal of Biochemistry & Cell Biology·Andréa Mariano-OliveiraChristina Barja-Fidalgo
Apr 26, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jill B LewisJohn C Wataha

❮ Previous
Next ❯

Citations

Apr 9, 2013·Journal of Materials Science. Materials in Medicine·Lufeng YuZana Mariano
Nov 19, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Estelle Cormet-BoyakaProsper N Boyaka
May 7, 2014·Marine Drugs·Maria Alessandra GammoneNicolantonio D'Orazio
Oct 26, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Marisa FreitasEduarda Fernandes
Mar 23, 2013·Toxicology Letters·Marisa FreitasEduarda Fernandes
Jun 16, 2012·Oxidative Medicine and Cellular Longevity·Elisa Couto GomesMarta Rubino de Oliveira
Jun 19, 2012·Free Radical Biology & Medicine·Jeong-Chae LeeXianglin Shi
Mar 14, 2019·Toxicology and Industrial Health·Runan QinYonghui Wu
Dec 4, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Zhongyu ZhangQ Ping Dou
Aug 16, 2011·Metallomics : Integrated Biometal Science·Marisa Freitas, Eduarda Fernandes
Jan 1, 2013·Journal of Biomarkers·Brahm Kumar TiwariSyed Ibrahim Rizvi
Aug 29, 2018·Frontiers in Immunology·Viktor ReshetnikovAndriy Mokhir
Dec 3, 2016·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Tadeusz HalatekWojciech Wasowicz
Feb 20, 2019·Frontiers in Immunology·Marion MussbacherJohannes A Schmid
Jan 12, 2021·Frontiers in Physiology·Simin Berenji ArdestaniIngrid Eftedal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Suresh Vir Singh Rana
Cell Death and Differentiation
B Geering, H-U Simon
© 2021 Meta ULC. All rights reserved