Nickel-keratinocyte interaction: a possible role in sensitization

The British Journal of Dermatology
M PicardoB Santucci

Abstract

Normal human keratinocytes and the keratinocyte-derived cell lines NCTC 2544 and A 431, were exposed for different periods (1-5 days) to various concentrations (0.023-46.6 micrograms/ml) of nickel (Ni2+). A dose- and time-dependent inhibition of cell growth and viability was observed. Cultures exposed to 2.3 micrograms Ni2+/ml showed approximately 50% cell survival at 5 days. An increase in release of interleukin 1 by keratinocytes was detected following culture for 24 h with a Ni2+ concentration of 2.3-11.5 micrograms/ml. Short periods of incubation (30 min) with these concentrations induced an activation of lipoxygenase in leucocytes from healthy subjects, without modifying cell viability. The results suggest that the percutaneous penetration of small amounts of Ni2+ can result in damage to keratinocytes and can initiate sensitization.

References

Feb 1, 1976·Environmental Research·M H Samitz, S A Katz
Oct 1, 1989·Contact Dermatitis·B SantucciM Picardo
Aug 1, 1988·Journal of the American Academy of Dermatology·E A EmmettS Feinman
Sep 1, 1988·Contact Dermatitis·B SantucciM Picardo
Nov 1, 1988·The British Journal of Dermatology·A Fullerton, A Hoelgaard
May 1, 1987·Contact Dermatitis·T MennéG Valeur
Jul 1, 1956·The British Journal of Dermatology·G C WELLS

❮ Previous
Next ❯

Citations

Jan 26, 1991·Lancet·J N BarkerB J Nickoloff
Jan 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S PastoreD N Sauder
Oct 13, 2010·Immunology and Cell Biology·Ben Roediger, Wolfgang Weninger
Jan 1, 1991·Archives of Dermatological Research·M PicardoG Prota
Mar 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Emanuela CorsiniAristidis M Tsatsakis
Nov 1, 1993·Contact Dermatitis·B SantucciM Picardo
Dec 25, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·V GalbiatiE Corsini
May 22, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Montserrat MitjansEmanuela Corsini
Apr 16, 1998·The British Journal of Dermatology·M C LittleS Mac Neil
Nov 1, 1991·The British Journal of Dermatology·J M McGregorD M MacDonald
Jan 1, 1993·Critical Reviews in Toxicology·J J HostýnekR H Guy
Jun 24, 2008·Journal of Immunotoxicology·Tomoki FukuyamaTakanori Harada
Jul 31, 2013·Expert Review of Medical Devices·John C WatahaWhasun O Chung
Nov 22, 2012·Current Protocols in Toxicology·Valentina Galbiati, Emanuela Corsini
Mar 1, 1992·Contact Dermatitis·J N Barker
Mar 1, 1999·Alternatives to Laboratory Animals : ATLA·E CorsiniC L Galli
Apr 29, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Emanuela CorsiniMarina Marinovich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.