Nickel-quinolones interaction. Part 2--interaction of nickel(II) with the antibacterial drug oxolinic acid

Journal of Inorganic Biochemistry
Kalliopi C SkyrianouGeorge Psomas

Abstract

The mononuclear nickel(II) complexes with the first-generation quinolone antibacterial agent oxolinic acid in the presence or absence of nitrogen-donor heterocyclic ligands (2,2'-bipyridine, 1,10-phenanthroline or pyridine) have been synthesized and characterized. The experimental data suggest that oxolinic acid acts as deprotonated bidentate ligand coordinated to Ni(II) ion through the ketone and carboxylato oxygens. The crystal structure of (2,2'-bipyridine)bis(oxolinato) nickel(II), 2 has been determined by X-ray crystallography. The cyclic voltammograms of the complexes recorded in dmso solution and in 1/2 dmso/buffer (containing 150mM NaCl and 15mM trisodium citrate at pH 7.0) solution have shown that in the presence of calf-thymus DNA (CT DNA) they can bind to CT DNA by the intercalative binding mode. UV study of the interaction of the complexes with CT DNA has shown that the complexes bind to CT DNA and bis(aqua)bis(oxolinato) nickel(II) exhibits the highest binding constant to CT DNA. Competitive study with ethidium bromide (EB) has shown that the complexes can displace the DNA-bound EB indicating that they bind to DNA in strong competition with EB. The complexes exhibit good binding propensity to human or bovine serum ...Continue Reading

Citations

Oct 3, 2014·Bioinorganic Chemistry and Applications·Anamika DebnathDhanraj T Masram
Jul 22, 2010·Expert Opinion on Therapeutic Patents·Jason A WilesMichael J Pucci
Sep 14, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina Uivarosi
Aug 26, 2014·European Journal of Medicinal Chemistry·Catherine ProtogerakiGeorge Psomas
Apr 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Filitsa DimizaGeorge Psomas
Oct 26, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Chun-Wei HsuMing-Hon Hou
May 10, 2020·International Journal of Environmental Research and Public Health·Xixi LiBing Chen
Mar 27, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·George Psomas, Dimitris P Kessissoglou

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