Nickel requirement of a urease-deficient mutant in Aspergillus nidulans

Journal of General Microbiology


The addition of nickel ions restored urease activity in vivo and ability to grow on urea in a mutant strain of Aspergillus nidulans otherwise unable to utilize urea. This train carries a mutation in the ureD locus, one of four loci involved in urea utilization. No other urease-deficient strains tested responded to the presence of nickel ions. The analogous characteristics of the ureD mutant and the nitrate reductase and xanthine dehydrogenase associated cnxE mutants in Aspergillus nidulans are discussed. It is postulated that the ureD locus is in some way involved in the production or incorporation of a nickel cofactor essential for urease activity.


Aug 1, 1982·Biochemical Genetics·E M Mackay, J A PATEMAN
Jun 28, 2003·FEMS Microbiology Reviews·Scott B Mulrooney, Robert P Hausinger
Jan 5, 2010·Metallomics : Integrated Biometal Science·Eric L CarterRobert P Hausinger
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·I S ParkRobert P Hausinger
Mar 23, 2011·Fungal Genetics and Biology : FG & B·Christos GournasC Scazzocchio
Feb 1, 1996·Canadian Journal of Microbiology·M W LubbersR J Thornton

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