Niclosamide suppresses RANKL-induced osteoclastogenesis and prevents LPS-induced bone loss

Biochemical and Biophysical Research Communications
Yoon-Hee CheonJaemin Oh

Abstract

Niclosamide (5-chloro-salicyl-(2-chloro-4-nitro) anilide) is an oral anthelmintic drug used for treating intestinal infection of most tapeworms. Recently, niclosamide was shown to have considerable efficacy against some tumor cell lines, including colorectal, prostate, and breast cancers, and acute myelogenous leukemia. Specifically, the drug was identified as a potent inhibitor of signal transducer and activator of transcription 3 (STAT3), which is associated with osteoclast differentiation and function. In this study, we assessed the effect of niclosamide on osteoclastogenesis in vitro and in vivo. Our in vitro study showed that receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation was inhibited by niclosamide, due to inhibition of serine-threonine protein kinase (Akt) phosphorylation, inhibitor of nuclear factor-kappaB (IκB), and STAT3 serine(727). Niclosamide decreased the expression of the major transcription factors c-Fos and NFATc1, and thereafter abrogated the mRNA expression of osteoclast-specific genes, including TRAP, OSCAR, αv/β3 integrin (integrin αv, integrin β3), and cathepsin K (CtsK). In an in vivo model, niclosamide prevented lipopolysaccharide-induced bone loss by dimin...Continue Reading

References

May 16, 2003·Nature·William J BoyleDavid L Lacey
Aug 18, 2004·The Journal of Clinical Investigation·Fumiyo IkedaToshiyuki Yoneda
Nov 9, 2005·The Journal of Experimental Medicine·Masataka AsagiriHiroshi Takayanagi
Feb 20, 2007·Annals of the New York Academy of Sciences·Dimitrios J Hadjidakis, Ioannis I Androulakis
Jun 19, 2007·Biochemical and Biophysical Research Communications·Betty LamotheBryant G Darnay
Oct 25, 2007·PloS One·Naohiro KawamuraHiroshi Kawaguchi
Jan 30, 2008·Experimental Parasitology·Karin Merschjohann, Dietmar Steverding
Nov 26, 2008·The Journal of Biological Chemistry·Susan R WilsonDieter Brömme
Oct 13, 2010·Annual Review of Pathology·Xu Feng, Jay M McDonald
Jun 21, 2011·Journal of the National Cancer Institute·Ulrike SackUlrike Stein
Nov 13, 2012·Biochemical and Biophysical Research Communications·Changhong LiXiangyuan Liu
Dec 24, 2013·Molecular Cancer Therapeutics·Shuo YouXingming Deng
Feb 21, 2014·Molecular Cancer Therapeutics·Angelina I Londoño-JoshiDonald J Buchsbaum
Feb 25, 2014·Cellular Immunology·Chieh-Shan WuChi-Chen Lin
Feb 25, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Liuqin LiangHanshi Xu

❮ Previous
Next ❯

Citations

May 7, 2020·Journal of Cellular Physiology·Palani DineshMahaboobkhan Rasool
Mar 15, 2021·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Letícia Sgarbi PintoPaulo Nelson-Filho
Nov 26, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jingyao CuiXin Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.