Abstract
Niclosamide (5-chloro-salicyl-(2-chloro-4-nitro) anilide) is an oral anthelmintic drug used for treating intestinal infection of most tapeworms. Recently, niclosamide was shown to have considerable efficacy against some tumor cell lines, including colorectal, prostate, and breast cancers, and acute myelogenous leukemia. Specifically, the drug was identified as a potent inhibitor of signal transducer and activator of transcription 3 (STAT3), which is associated with osteoclast differentiation and function. In this study, we assessed the effect of niclosamide on osteoclastogenesis in vitro and in vivo. Our in vitro study showed that receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation was inhibited by niclosamide, due to inhibition of serine-threonine protein kinase (Akt) phosphorylation, inhibitor of nuclear factor-kappaB (IκB), and STAT3 serine(727). Niclosamide decreased the expression of the major transcription factors c-Fos and NFATc1, and thereafter abrogated the mRNA expression of osteoclast-specific genes, including TRAP, OSCAR, αv/β3 integrin (integrin αv, integrin β3), and cathepsin K (CtsK). In an in vivo model, niclosamide prevented lipopolysaccharide-induced bone loss by dimin...Continue Reading
References
Nov 26, 1999·Bone·N UdagawaT Suda
Dec 14, 2002·Developmental Cell·Hiroshi TakayanagiTadatsugu Taniguchi
Mar 15, 2003·Blood·Hongtao LiuRichard M Pope
May 16, 2003·Nature·William J BoyleDavid L Lacey
Aug 12, 2004·The Journal of Biological Chemistry·Masahito MatsumotoYasuhisa Nogi
Aug 18, 2004·The Journal of Clinical Investigation·Fumiyo IkedaToshiyuki Yoneda
Nov 17, 2004·The Journal of Biological Chemistry·Toshifumi Sugatani, Keith A Hruska
Aug 20, 2005·The Journal of Biological Chemistry·Kabsun KimNacksung Kim
Nov 9, 2005·The Journal of Experimental Medicine·Masataka AsagiriHiroshi Takayanagi
Mar 4, 2006·Gene·Tania N CrottiKevin P McHugh
Feb 20, 2007·Annals of the New York Academy of Sciences·Dimitrios J Hadjidakis, Ioannis I Androulakis
Jun 19, 2007·Biochemical and Biophysical Research Communications·Betty LamotheBryant G Darnay
Sep 22, 2007·Molecular Endocrinology·Kabsun KimNacksung Kim
Oct 25, 2007·PloS One·Naohiro KawamuraHiroshi Kawaguchi
Jan 30, 2008·Experimental Parasitology·Karin Merschjohann, Dietmar Steverding
Nov 26, 2008·The Journal of Biological Chemistry·Susan R WilsonDieter Brömme
Jan 23, 2009·Journal of Cellular Biochemistry·An-Ming WangTien-Shun Yeh
Oct 13, 2010·Annual Review of Pathology·Xu Feng, Jay M McDonald
May 3, 2011·Cancer Research·Takuya OsadaH Kim Lyerly
Jun 21, 2011·Journal of the National Cancer Institute·Ulrike SackUlrike Stein
Dec 24, 2011·PloS One·Wenyan LuYonghe Li
Nov 13, 2012·Biochemical and Biophysical Research Communications·Changhong LiXiangyuan Liu
Nov 28, 2012·PloS One·Juncheng WeiJian Wang
Dec 24, 2013·Molecular Cancer Therapeutics·Shuo YouXingming Deng
Feb 21, 2014·Molecular Cancer Therapeutics·Angelina I Londoño-JoshiDonald J Buchsbaum
Feb 25, 2014·Cellular Immunology·Chieh-Shan WuChi-Chen Lin
Feb 25, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Liuqin LiangHanshi Xu
Jun 30, 2015·Current Cancer Drug Targets·Zhan LiaoZhongliang Wang
Citations
May 7, 2020·Journal of Cellular Physiology·Palani DineshMahaboobkhan Rasool
Jun 13, 2020·Aging·Yueqi ChenShiwu Dong
Jul 1, 2020·FEBS Open Bio·Yurui JiaoYikun Zhu
Mar 15, 2021·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Letícia Sgarbi PintoPaulo Nelson-Filho
Jun 19, 2019·Experimental Cell Research·Xuzhuo ChenShanyong Zhang
Jun 14, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fei CongGao Chao
Nov 26, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jingyao CuiXin Li