Nicorandil ameliorates posttransplant dysfunction in cardiac allografts harvested from non-heart-beating donors

The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi
Makoto MohriShunji Sano

Abstract

Warm ischemia is a major cause of cardiac allograft dysfunction in non-heart-beating donors (NHBDs). We evaluated the cardioprotective effects of nicorandil, an adenosine triphosphate-sensitive potassium channel opener, on the early posttransplant left ventricular (LV) function of hearts harvested from asphyxiated canine NHBDs. Hypoxic cardiac arrest was induced in 12 donor dogs. In 6, nicorandil was administered intravenously at 100 micrograms/kg + 25 micrograms/kg/min after respiratory arrest and hearts were preserved with nicorandil-supplemented cardioplegic solution (nicorandil group). The remaining 6 did not receive nicorandil at any time during the experiment (control group). Hearts were orthotopically transplanted after a mean myocardial ischemic time of 4 hours. All 12 recipients were weaned from cardiopulmonary bypass without inotropic support. In the control group, posttransplant cardiac indices and left ventricular end-systolic pressure (LVESP) decreased significantly, while LV max-dP/dt and Tau increased over pretransplant values. No differences were seen in parameters between pretransplant and posttransplant values in the nicorandil group. Posttransplant cardiac indices, LVESP, and LV max + dP/dt were higher in the...Continue Reading

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·G J GrossG M Pieper
Jan 1, 1992·Journal of Cardiovascular Pharmacology·A von NiecieckiF Stanislaus
Jun 1, 1992·Cardiovascular Drugs and Therapy·G M Pieper, G J Gross
Mar 1, 1992·The Annals of Thoracic Surgery·R ShirakuraY Kawashima
May 1, 1992·The Annals of Thoracic Surgery·S R GundryL L Bailey
Jan 27, 1995·Transplantation·A CasavillaT Starzl
Jul 1, 1996·The Annals of Thoracic Surgery·M C MauneyC G Tribble
Feb 24, 2001·The Annals of Thoracic Surgery·K SuehiroS Sano
Mar 27, 2001·Lancet·S SteenL Algotsson

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Citations

Apr 19, 2019·Circulation. Heart Failure·Petra NiederbergerSarah L Longnus
Mar 1, 2018·Frontiers in Cardiovascular Medicine·Christopher W WhiteDarren H Freed

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