Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo

European Journal of Pharmacology
Jürgen BiermannMichael Brunner


Transgenic rabbits expressing loss-of-function pore mutants of the human gene KCNQ1 (K(v)LQT1-Y315S) have a Long QT-Syndrome 1 (LQT1) phenotype. We evaluated for the first time the effect of nicorandil, an opener of ATP-sensitive potassium channels, and of isoproterenol on cardiac action potential duration and heart rate dependent dispersion of repolarisation in transgenic LQT1 rabbits. In vivo LQT1 and littermate control were subjected to transvenous electrophysiological studies; in vitro monophasic action potentials were recorded from explanted Langendorff-perfused hearts. In vivo ventricular effective refractory periods (VERP) at the right ventricular base were significantly prolonged in LQT1 as compared to littermate control, resulting in a more pronounced VERP dispersion in LQT1. This difference in VERP dispersion between LQT1 and littermate control disappeared after infusion of nicorandil. In vitro, mean action potential durations (APD(75) and APD(90)) of LQT1 were significantly prolonged compared to littermate control at baseline. Nicorandil decreased APD(75) and APD(90) in LQT1 and littermate control at all stimulated heart rates. After adding nicorandil, the APD(90) at all hearts rates and the APD(75) at high heart rat...Continue Reading


Jan 1, 1992·Journal of Cardiovascular Pharmacology·N TreeseJ Meyer
Mar 1, 1989·The Journal of Clinical Investigation·D W FrazierR E Ideker
Jan 1, 1988·Circulation·J M SmithR J Cohen
Aug 1, 1993·Circulation·P J SchwartzR S Crampton
Jul 1, 1996·Pacing and Clinical Electrophysiology : PACE·W ShimizuK Shimomura
Feb 10, 1998·Journal of Cardiovascular Pharmacology·J ImagawaD M Yellon
Jul 18, 2000·Journal of the American College of Cardiology·F E Cruz FilhoJ C Ribeiro
Mar 29, 2001·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·S G PrioriL Crotti
Jun 2, 2001·Journal of Cardiovascular Electrophysiology·H R LuF De Clerck
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M BrunnerG Koren
Jan 18, 2002·Journal of Applied Physiology·Bruce D Nearing, Richard L Verrier
May 30, 2002·Journal of Cardiovascular Electrophysiology·Jeanne M Nerbonne, Weinong Guo
Aug 24, 2002·Circulation Research·Bum-Rak ChoiGuy Salama
Dec 13, 2002·Prenatal Diagnosis·Ing-Kuang ChangFon-Jou Hsieh
May 9, 2003·The New England Journal of Medicine·G Michael Vincent
Jul 15, 2004·Journal of Cardiovascular Electrophysiology·Salim F Idriss, Patrick D Wolf
Apr 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Thomas P FlaggColin G Nichols
May 10, 2008·The Journal of Clinical Investigation·Michael BrunnerGideon Koren
Jul 9, 2008·Orphanet Journal of Rare Diseases·Lia CrottiPeter J Schwartz
Oct 7, 2008·Current Problems in Cardiology·Ilan GoldenbergArthur J Moss
Oct 7, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Katja E OdeningGideon Koren
Nov 26, 2008·Progress in Cardiovascular Diseases·Wojciech Zareba, Iwona Cygankiewicz
Nov 26, 2008·Progress in Biophysics and Molecular Biology·Matthew J KilleenChristopher L-H Huang
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