Nicotiana glauca (tree tobacco) intoxication--two cases in one family.

Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology
Victoria FurerShoshana Zevin

Abstract

We present two cases of rare human poisoning in one family following ingestion of cooked leaves from the tobacco tree plant, Nicotiana glauca. The toxic principle of N. glauca, anabasine (C10H14N2), is a small pyridine alkaloid, similar in both structure and effects to nicotine, but appears to be more potent in humans. A 73-year-old female tourist from France, without remarkable medical history, collapsed at home following a few hours long prodrome of dizziness, nausea, vomiting, and malaise. The symptoms developed shortly after eating N. glauca cooked leaves that were collected around her daughter's house in Jerusalem and mistaken for wild spinach. She was found unconscious, with dilated pupils and extreme bradycardia. Following resuscitation and respiratory support, circulation was restored. However, she did not regain consciousness and died 20 days after admission because of multi-organ failure. Anabasine was identified by gas chromatography/mass spectrometry method in N. glauca leaves and in the patient's urine. Simultaneously, her 18-year-old grandson developed weakness and myalgia after ingesting a smaller amount of the same meal. He presented to the same emergency room in a stable condition. His exam was remarkable only ...Continue Reading

References

May 1, 1988·Pharmacology, Biochemistry, and Behavior·J W SloanE Wala
Jan 1, 1987·Journal of Toxicology. Clinical Toxicology·J L CastorenaR F Shaw
Oct 1, 1982·Journal of Toxicology. Clinical Toxicology·A S Manoguerra, D Freeman
Jul 1, 1993·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·K H PlumleeF D Galey
Oct 27, 1998·Clinics in Dermatology·S ZevinN L Benowitz
Jun 26, 1999·Annals of Emergency Medicine·L B MellickR Borger
Feb 24, 2001·Plant Molecular Biology·S J SinclairJ D Hamill
Aug 25, 2006·Clinical Pediatrics·Nancy G MurphyNeal L Benowitz
Sep 26, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Leo J SchepD Michael G Beasley

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Citations

May 28, 2013·La Presse médicale·Jean-Guillaume LopezLuc de Haro
Dec 12, 2012·Toxicology and Applied Pharmacology·Kevin D WelchDale R Gardner
Dec 18, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Benedict T GreenKip E Panter
Mar 28, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Benedict T GreenDavid R Brown
Dec 14, 2011·Journal of Ethnopharmacology·Guillermo BenítezJoaquín Molero-Mesa
Apr 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Benedict T GreenKip E Panter
Jul 30, 2014·Journal of Ethnopharmacology·Flávia dos Santos SilvaJúlio Marcelino Monteiro
Oct 3, 2018·Advanced Pharmaceutical Bulletin·Jirapornchai SuksaereeWiwat Pichayakorn
Sep 15, 2020·Clinical Practice and Cases in Emergency Medicine·Breelan M KearAnthony Arguija
Sep 30, 2017·Chemical Reviews·Amir Reza JassbiMeredith C Schuman

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