PMID: 4286359Apr 22, 1966Paper

Nicotinamide-adenine dinucleotide in tubercle bacilli exposed to isoniazid

Science
A Bekierkunst

Abstract

There is a decrease in the content of nicotinamide-adenine dinucleotide of tubercle bacilli grown in the presence of isoniazid. In extracts of tubercle bacilli, the activity of nicotinamide-adenine dinucleotidase is nil or very small; after incubation with the drug the enzyme becomes active. Isoniazid also increases the activity of the enzyme after it is partially activated by heating. There may be a correlation between the capacity of isoniazid to activate the enzyme and the decrease in the dinucleotide content of the tubercle bacilli.

References

May 1, 1964·The Biochemical Journal·K P GopinathanC S Vaidyanathan
May 1, 1963·The Biochemical Journal·K P GOPINATHANT RAMAKRISHNAN
Apr 1, 1964·Archives of Biochemistry and Biophysics·M ARTMANI GOLDENBERG
Aug 19, 1964·Biochimica Et Biophysica Acta·F WINDER, P BRENNAN
Dec 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·E KUNH GRUNICKE

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Citations

Mar 1, 1974·Antimicrobial Agents and Chemotherapy·G J Tritz
Nov 24, 2007·Annual Review of Microbiology·Catherine Vilchèze, William R Jacobs
Sep 5, 1968·Annals of the New York Academy of Sciences·A Bekierkunst
Oct 6, 1972·Biochemical and Biophysical Research Communications·A J AndreoliT A Grover
Mar 20, 1967·Archives of Biochemistry and Biophysics·A Bekierkunst
Nov 1, 1967·Archives of Biochemistry and Biophysics·A Bekierkunst, A Bricker
Feb 2, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Inara de AguiarDouglas W Franco
Sep 11, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ameeruddin Nusrath UnissaNagamiah Selvakumar
Dec 25, 2007·The Journal of Antimicrobial Chemotherapy·Petros C KarakousisWilliam R Bishai
May 1, 2007·Personalized Medicine·Cedric J WerelyPaul D van Helden
Jun 11, 1998·Journal of Bacteriology·R CantoniG Riccardi
Feb 16, 2021·Frontiers in Microbiology·Kyle H Rohde, Leonardo Sorci
Jun 25, 2015·Microbiology Spectrum·Catherine Vilchèze, William R Jacobs

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