Nicotinamide enhances skin flap survival.

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
T M CollinsY R Smith

Abstract

The effects of nicotinamide in an abdominal island pedicle skin flap were examined. A 7 x 7 cm island pedicle skin flap ligating the left inferior neurovascular pedicle was created on 50 male Sprague Dawley rats (250-275 grams) that were divided into five groups. Animals received either 0.6 cc of saline or doses of nicotinamide for 16 days (14 days preoperatively and 2 days postoperatively): 25 mg b.i.d., 50 mg b.i.d., 100 mg b.i.d. or 200 mg b.i.d. Forty-eight hours postoperatively each animal received 25 mg of Fluorescein via the tail vein. The area of necrosis was visualized and quantified and is presented as % survival. A one factor Fisher PLSD test was performed with a statistical significance of p less than 0.05 with the results as follows: saline 58.8%, 25 mg 68.6%, 50 mg 82%, 100 mg 80.8%, and 200 mg 86%. From this data it would appear that the angiogenic factor nicotinamide may increase random flap survival.

References

May 1, 1978·Plastic and Reconstructive Surgery·F Finseth, M G Adelberg
Jan 23, 1987·Science·J Folkman, M Klagsbrun
May 15, 1987·Science·F C KullP Cuatrecasas
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Jan 1, 1985·Advances in Cancer Research·J Folkman
May 1, 1986·Plastic and Reconstructive Surgery·M F AngelJ W Futrell
Sep 1, 1986·Regulatory Toxicology and Pharmacology : RTP·I W DavidsonR P Beliles
Aug 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P M NemiroffN J Cassisi
Nov 29, 1973·The New England Journal of Medicine·S L Winter, J L Boyer
Feb 1, 1971·The Journal of Experimental Medicine·J FolkmanG Williams
Dec 1, 1971·Canadian Psychiatric Association Journal·A Hoffer
Jun 1, 1984·Journal of Microscopy·D A Silage, J Gil
Feb 1, 1984·Plastic and Reconstructive Surgery·M J ImJ E Hoopes
Jul 1, 1982·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R E Marx, J R Ames

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Citations

Nov 19, 2002·Clinics in Dermatology·Ronni WolfBinnur Tüzün
Apr 7, 2006·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
Jul 16, 2005·Journal of Periodontology·Rodrigo F NeivaHom-Lay Wang
May 6, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Georg M HuemerHarald Schoffl
Jul 2, 2003·Journal of Clinical Periodontology·Rodrigo F NeivaHom-Lay Wang
Jan 5, 2008·International Journal of Dermatology·Mohammad R Namazi
Jan 1, 1991·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·T M CollinsY R Smith

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