Nicotinamide Improves Functional Recovery via Regulation of the RAGE/JNK/NF-κB Signaling Pathway after Brain Injury

Journal of Clinical Medicine
Sayed Ibrar AlamMyeong Ok Kim

Abstract

Brain injuries are a serious global health issue and are the leading cause of neurodegeneration. To date, there is no proper cure and treatment for brain-injury-induced neuropathological conditions because of a lack of sufficient knowledge and the failure to develop a drug due to the multi-pathological conditions in the brain. Herein, we explored the neurotherapeutic effects of Nicotinamide (NAM), against brain injury-induced neurodegeneration and behavioral problems. Treating injured mouse brains with NAM, for 7 days, significantly ameliorated several pathological events. Interestingly, NAM treatment significantly inhibited the injury-induced activation of receptor for advanced glycation end-products (RAGE), c-Jun N-terminal kinases (JNK), and neuroinflammatory mediators, such as NF-κB, TNF-α, IL-1β, and NOS2 in the brain, and it also regulated the levels of apoptotic markers, including Bax, caspase-3, and Bcl-2. Furthermore, treatment using NAM in TBI mice, significantly reversed synaptic protein loss and improved memory impairments and behavioral outcomes. Our findings suggested that NAM treatment reduced injury-induced secondary neurodegenerative pathology by modulating RAGE/JNK/NF-κB signaling in mice. Therefore, we recomm...Continue Reading

References

May 20, 1999·Annual Review of Pharmacology and Toxicology·T P DaltonA Puga
Feb 8, 2002·Molecular Neurobiology·P M LenzlingerT K McIntosh
Apr 27, 2005·Brain Research. Brain Research Reviews·Oliver I SchmidtPhilip F Stahel
May 27, 2008·Free Radical Biology & Medicine·Mubeen A AnsariStephen W Scheff
Apr 24, 2009·Journal of Alzheimer's Disease : JAD·Shi Du YanDavid M Stern
May 7, 2009·Neuroscience Letters·Coleen M AtkinsW Dalton Dietrich
Nov 26, 2010·The Psychiatric Clinics of North America·Silvana Riggio
Oct 25, 2011·Journal of Neurotrauma·Tommy SaingElizabeth Head
Jan 31, 2012·Experimental Neurology·Victoria E JohnsonDouglas H Smith
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
Jan 9, 2014·Restorative Neurology and Neuroscience·Neelima B Chauhan
Mar 14, 2014·Redox Biology·Christiane OttAndreas Simm
Apr 24, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stephanie L AungstAlan I Faden
Sep 25, 2014·Journal of Cellular Physiology·Sandra A AcostaCesar V Borlongan
Nov 7, 2014·Frontiers in Neurology·Ibolja CernakStefan Plantman
Jul 16, 2015·Cellular and Molecular Neurobiology·Zhiyou CaiBin Zhao
Jan 8, 2016·Brain Research·Sarah HellewellMaria Cristina Morganti-Kossmann
Jan 23, 2016·Frontiers in Pharmacology·Ramon YarzaMaria J Ramirez
Jun 18, 2016·Oxidative Medicine and Cellular Longevity·S PirasM Nitti
Mar 24, 2017·Neuroscience Letters·Zhiwen YaoPeng Jia
May 13, 2017·International Journal of Molecular Medicine·Li MaShang-Long Yao

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Citations

Mar 30, 2021·Ageing Research Reviews·Rohan GuptaPravir Kumar

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Methods Mentioned

BETA
electrophoresis
Fluorescence
confocal microscopy

Software Mentioned

ImageJ
- Pad Prism
sigma Gel
Graph
SPSS

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Brain Injury & Trauma

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