Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse

Pharmacological Reports : PR
Magdalena SternakStefan Chłopicki

Abstract

Nicotinamide N-methyltransferase (NNMT), which converts nicotinamide (NA) to 1-methylnicotinamide (MNA), is up-regulated in the cirrhotic liver. Because MNA displays PGI(2)-dependent anti-inflammatory effects, the up-regulation of NNMT may play a regulatory role in liver inflammation. In the present work, we analyzed changes in NNMT activity in the liver and concomitant changes in the concentration of endogenous MNA in plasma in T-cell dependent hepatitis induced by concanavalin A (ConA) in BALB/c mice. Furthermore, we tested whether exogenous MNA possessed a protective effect against ConA-induced hepatitis. Development of liver injury induced by ConA (10 mg/kg, iv) was characterized by measurements of plasma concentration of alanine aminotransaminase (ALT), inflammatory cytokines (INF gamma and TNFalpha) and by histopathological examination. ConA-induced hepatitis was characterized by an early activation of inflammatory cytokines (IFN gamma; from below 0.05 ng/ml to 23.72 +/- 8.80 ng/ml; TNFalpha;from 0.07 +/- 0.01 ng/ml to 0.71 +/- 0.12 ng/ml, 2 h after ConA), an elevation of ALT (from 40.65 +/- 3.2 U/l to 5,092.20 +/- 1,129.05 U/l, 8 h after ConA) and by morphological signs of severe liver inflammation and injury (24 h after...Continue Reading

References

Mar 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·G B BarlowA W Wilkinson
Jul 1, 1992·The Journal of Clinical Investigation·G TiegsA Wendel
Jan 31, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·J RiniR M Weinshilboum
Dec 1, 1989·Chemical & Pharmaceutical Bulletin·A SanoS Takitani
Jul 1, 1971·Archives of Biochemistry and Biophysics·M Stanulović, S Chaykin
Sep 28, 1984·Biochimica Et Biophysica Acta·R SeifertH Kröger
Feb 15, 1994·Biochemical and Biophysical Research Communications·T C WoodR M Weinshilboum
Jan 1, 1994·Journal of Hepatology·R CuomoG Budillon
Apr 1, 1997·Journal of Nutritional Science and Vitaminology·Y EgashiraH Sanada
Nov 27, 1999·Journal of Nutritional Science and Vitaminology·Y EgashiraH Sanada
Aug 30, 2002·Neurotoxicology and Teratology·Kazuo MatsubaraToshio Awaya
Sep 21, 2002·Cytokine·Gabriele SassGisa Tiegs
Nov 7, 2002·Biochemical and Biophysical Research Communications·Hongyan DongKouji Matsushima
Sep 16, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Satoshi OhtaHajime Nawata
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Markus RoesslerMichael Tacke
Oct 9, 2007·Journal of Cancer Research and Clinical Oncology·Mikio TomidaMasafumi Kurosumi
Oct 16, 2007·European Journal of Pharmacology·Krzysztof BryniarskiJanusz Marcinkiewicz
Apr 4, 2008·The Journal of Pharmacology and Experimental Therapeutics·Tomasz BrzozowskiWieslaw W Pawlik
Nov 11, 2008·Atherosclerosis·Monika RiedererRudolf Zechner
Feb 17, 2009·Journal of Experimental & Clinical Cancer Research : CR·Jongmin KimDae Shick Kim
Feb 27, 2009·Journal of Cancer Research and Clinical Oncology·Mikio TomidaHirohiko Akiyama
Mar 25, 2009·Pharmacological Reports : PR·Cezary WatałaStefan Chłopicki
Jun 9, 2009·Acta Cirúrgica Brasileira·Ercan GedikHuseyin Buyukbayram
Mar 13, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Malgorzata SzafarzJoanna Szymura-Oleksiak

❮ Previous
Next ❯

Citations

Oct 13, 2015·Biochemical and Biophysical Research Communications·Karolina Y LiuRichard B Parsons
Jul 23, 2013·Journal of Biochemical and Molecular Toxicology·Zeinab H MilaniRichard B Parsons
Jul 15, 2016·Journal of Experimental & Clinical Cancer Research : CR·Agnieszka BlazejczykJoanna Wietrzyk
Oct 11, 2016·International Immunopharmacology·Xianli YuanMingcai Li
Nov 18, 2017·The International Journal of Biological Markers·Valentina PozziMonica Emanuelli
Jan 8, 2020·Journal of Biochemical and Molecular Toxicology·Rakhee J MistryRichard B Parsons
Jul 4, 2018·Oxidative Medicine and Cellular Longevity·Andrzej FedorowiczStefan Chlopicki
Jan 13, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Lili FuSusu Tang
Jan 3, 2021·Molecular Neurobiology·Altin KocinajRichard B Parsons
Jun 22, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Roberto CampagnaStefan Chlopicki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here