Nicotinamide phosphoribosyltransferase leukocyte overexpression in Graves' opthalmopathy

Endocrine
Nadia Sawicka-GutajMarek Ruchała

Abstract

To investigate the role of NAMPT/visfatin in euthyroid patients with Graves' disease without (GD) and with Graves' ophthalmopathy (GO), we analyzed NAMPT leukocyte expression and its serum concentration. This was a single-center, cross-sectional study with consecutive enrollment. In total, 149 patients diagnosed with Graves' disease were enrolled in the study. We excluded subjects with hyper- or hypothyroidism, diabetes mellitus, other autoimmune disorders, active neoplastic disease, and infection. The control group was recruited among healthy volunteers adjusted for age, sex, and BMI with normal thyroid function and negative thyroid antibodies. Serum levels of visfatin, TSH, FT4, FT3, antibodies against TSH receptor (TRAb), antithyroperoxidase antibodies, antithyroglobulin antibodies, fasting glucose, and insulin were measured. NAMPT mRNA leukocyte expression was assessed using RT-qPCR. NAMPT/visfatin serum concentration was higher in GD (n = 44) and GO (n = 49) patients than in the control group (n = 40) (p = 0.0275). NAMPT leukocyte expression was higher in patients with GO (n = 30) than in GD patients (n = 27) and the control group (n = 29) (p < 0.0001). Simple linear regression analysis revealed that NAMPT/visfatin serum c...Continue Reading

References

Oct 20, 2005·The Journal of Clinical Endocrinology and Metabolism·Miao-Pei ChenYau-Jiunn Lee
Feb 24, 2006·Clinical Science·Katarzyna KrzyzanowskaGuntram Schernthaner
Jul 4, 2006·American Journal of Ophthalmology·James A Garrity, Rebecca S Bahn
Jan 31, 2008·European Journal of Endocrinology·K M ChoiC G Park
Feb 7, 2008·Journal of Leukocyte Biology·Tracy LukJohn C Marshall
Feb 27, 2008·European Journal of Endocrinology·Luigi BartalenaUNKNOWN European Group on Graves' Orbitopathy (EUGOGO)
Dec 26, 2008·Trends in Endocrinology and Metabolism : TEM·Antje GartenWieland Kiess
Apr 13, 2011·Handbook of Experimental Pharmacology·Antje GartenWieland Kiess
Apr 3, 2012·Annual Review of Nutrition·Tuva B DahlBente Halvorsen
Apr 11, 2012·The British Journal of Dermatology·S A Ismail, S A Mohamed
Nov 28, 2012·European Journal of Endocrinology·Rudolf HoermannJohannes W Dietrich
Jan 4, 2013·The Journal of Clinical Endocrinology and Metabolism·Irina KowalskaMarek Straczkowski
Dec 24, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kui ZhangLin Zhang
Feb 20, 2014·Endokrynologia Polska·Nadia Sawicka-GutajMarek Ruchała
May 8, 2014·Endokrynologia Polska·Marzena WójcikKatarzyna Cypryk
May 29, 2014·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F A VerburgC Reiners
Jun 20, 2014·World Journal of Gastroenterology : WJG·Marek WalugaKrystyna Zwirska-Korczala
Jul 26, 2014·PloS One·Beata Jurecka-LubienieckaBarbara Jarzab
Oct 1, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jerzy SowińskiMarek Ruchała
Oct 11, 2014·Endokrynologia Polska·Marek RuchałaAriadna Zybek
Oct 11, 2014·Endokrynologia Polska·Piotr MiśkiewiczTomasz Bednarczuk
Feb 25, 2015·Pharmacology & Therapeutics·Deepak SampathPeter S Dragovich
Mar 10, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·R Le MoliR Vigneri
May 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nadia Sawicka-GutajMarek Ruchała
Sep 2, 2015·Endokrynologia Polska·Nadia Sawicka-GutajMarek Ruchała

❮ Previous
Next ❯

Citations

Mar 12, 2016·Expert Review of Clinical Pharmacology·Marek Ruchała, Nadia Sawicka-Gutaj
Apr 8, 2020·Experimental and Therapeutic Medicine·Jia-Zhen TangXiao-Xue Zheng
Jul 22, 2020·Clinical Endocrinology·Yip Han ChinChin Meng Khoo
Jul 23, 2020·Mediators of Inflammation·Bogusz FalkowskiMarek Ruchala
Mar 4, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ming Hui LeeChin Meng Khoo
Sep 23, 2021·Scientific Reports·Nadia Sawicka-GutajMarek Ruchała

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
ELISA
PCR

Software Mentioned

MedCalc

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.