Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance

Experimental Physiology
I A KourtzidisM G Nikolaidis

Abstract

What is the central question of this study? The aim was to investigate the potential metabolic and redox mechanisms that impaired exercise performance after 21 days of supplementation with 300 mg (kg body weight)-1 of nicotinamide riboside in rats. What is the main finding and its importance? Nicotinamide riboside disturbed energy and redox metabolism and impaired exercise performance in heathy rats. Exogenously administered redox agents in heathy populations might lead to adverse effects. Nicotinamide riboside is a recently discovered form of vitamin B3 that can increase NAD(P) levels. NAD(P) plays key roles in energy metabolism, and its main function is the transfer of electrons in various cellular reactions. Research in aged or diseased mice reported that nicotinamide riboside increases NAD(H) levels, reduces morbidity and improves health and muscle function. We have recently shown that in healthy young rats, chronic administration of nicotinamide riboside marginally non-significantly decreased exercise performance by 35% (P = 0.071). As a follow-up to this finding, we analysed samples from these animals, in an attempt to reveal the potential mechanisms driving this adverse effect, focusing on redox homeostasis and bioenerge...Continue Reading

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Citations

May 30, 2019·Rejuvenation Research·Andrew R Mendelsohn, James W Larrick
May 27, 2020·International Journal of Sports Medicine·Michalis G NikolaidisAntonios Matsakas
Jan 9, 2021·Oxidative Medicine and Cellular Longevity·Borut PoljsakIrina Milisav
Jul 10, 2021·Journal of the International Society of Sports Nutrition·Bagen LiaoMin Hu
Aug 10, 2021·Frontiers in Medicine·Jing XuDaisuke Koya

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