Nicotine Acutely Enhances Reinforcement from Non-Drug Rewards in Humans

Frontiers in Psychiatry
K A PerkinsMargaret C Boldry

Abstract

Preclinical research documents that, aside from the primary and secondary reinforcing effects of nicotine intake itself, nicotine also acutely enhances the reinforcing efficacy of non-drug reinforcers ("rewards"). Study of these effects in humans has largely been overlooked, but very recent findings suggest they may have clinical implications for more fully understanding the persistence of tobacco dependence. This overview first outlines the topic and notes some recent human studies indirectly addressing nicotine effects on related responses (e.g., subjective ratings), explaining why those findings do not directly confirm enhancement of behavioral reinforcement per se due to nicotine. Then, the methodology used in the subsequently presented studies is described, demonstrating how those studies specifically did demonstrate enhancement of reinforced responding for non-drug rewards. The main section focuses on the limited controlled research to date directly assessing nicotine's acute reinforcement-enhancing effects in humans, particularly as it relates to reinforced behavioral responding for non-drug rewards in non-human animal models. After detailing those few existing human studies, we address potential consequences of these ef...Continue Reading

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Citations

Mar 8, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth A PerkinsMargaret C Boldry
Apr 29, 2018·Psychopharmacology·Youna VandaeleStephanie Caille
Mar 28, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Merideth A AddicottF Joseph McClernon
Dec 15, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Nancy C JaoBrian Hitsman
Jun 23, 2020·Substance Use & Misuse·Roger L PapkeThaddeus A Herzog
Jul 29, 2020·Substance Use & Misuse·Alexandra N Palmisano, Robert S Astur
May 20, 2018·Psychopharmacology·Joshua L Karelitz, Kenneth A Perkins
Jul 19, 2019·Biology of Sex Differences·Sierra J StringfieldDonita L Robinson
Aug 6, 2019·Frontiers in Behavioral Neuroscience·Vernon Garcia-RivasVéronique Deroche-Gamonet
Nov 15, 2020·Molecular Psychiatry·Wilson M ComptonRobert L DuPont
Oct 17, 2020·Journal of Health Communication·Jennifer C MorganJoseph N Cappella
Nov 21, 2020·Journal of Psychiatry and Brain Science·Daniel SazhinDavid V Smith
Apr 24, 2021·Psychopharmacology·Salma TannousStephanie Caille
Apr 30, 2021·Frontiers in Behavioral Neuroscience·Thach HuynhNeil Schmitzer-Torbert
Jun 5, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Nancy C JaoBrian Hitsman

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