Nicotine administration significantly alters accumbal dopamine in the adult but not in the adolescent rat

Annals of the New York Academy of Sciences
Kimberly A Badanich, Cheryl L Kirsteina

Abstract

Many drug-dependent adults began using drugs during adolescence. In fact, adolescent drug users are more likely to become drug-dependent adults than those abstaining from drug use until after the age of 18. Because of this, recent research has begun to investigate the consequences of adolescent drug use. Specifically, research has begun to focus on the behavioral effects of drugs on the developing brain and the development of drug addiction. The present study examined the responsiveness of the mesolimbic dopamine (DA) pathway during development through the use of in vivo microdialysis. Specifically, it was determined whether nicotine-induced accumbal DA release differs between adolescent and adult rats. To assess nicotine's effects across age, animals received acute or repeated nicotine at early adolescence (postnatal day (PND) 35), late adolescence (PND 45), or young adulthood (PND 60). Findings suggest that there are significant differences between adolescent and adult animals in their dopaminergic response to nicotine. Adult animals had an enhanced DA response to acute nicotine challenge, an effect absent in adolescence. Additionally, this nicotine-induced increase in adults was not apparent after repeated nicotine treatment...Continue Reading

References

Apr 1, 1992·British Journal of Pharmacology·M E Benwell, D J Balfour
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·E Museo, R A Wise
Sep 23, 1987·European Journal of Pharmacology·G MereuT C Westfall
Dec 16, 1986·European Journal of Pharmacology·A ImperatoG Di Chiara
Aug 1, 1982·Pharmacology, Biochemistry, and Behavior·R A Wise, M A Bozarth
May 1, 1996·Molecular and Chemical Neuropathology·C Vidal
Jun 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D A Lewis
Jan 29, 2000·European Journal of Pharmacology·C Cadoni, G Di Chiara
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Sep 15, 2001·Brain Research. Developmental Brain Research·R M PhilpotC L Kirstein
Aug 15, 2002·Neurochemistry International·Donald C Cooper
Sep 6, 2002·Physiology & Behavior·Bonnie J VastolaLinda P Spear
Oct 23, 2002·Journal of Neurochemistry·Steven Z ChaoMarina E Wolf
Dec 21, 2002·The European Journal of Neuroscience·Mischa de RoverArjen B Brussaard
Jan 15, 2003·The Journal of School Health·UNKNOWN Office on Smoking and Health, Division of Adolescent and School Health National Center for Chronic Disease Prevention and He

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Citations

Jul 1, 2006·Critical Reviews in Neurobiology·Sari Izenwasser
Dec 17, 2009·Neurochemical Research·A Lajtha, H Sershen
Jul 5, 2008·Brain Research Bulletin·E ShearmanA Lajtha
Nov 27, 2008·Alcoholism, Clinical and Experimental Research·Heidi KemppainenKalervo Kiianmaa
Aug 29, 2013·The Journal of Comparative Neurology·Leora YetnikoffDaniel S Zahm
Nov 30, 2006·Neurotoxicology and Teratology·Eric P Nolley, Brian M Kelley
Mar 5, 2015·Pharmacology, Biochemistry, and Behavior·Magalie LenoirSari Izenwasser
Mar 3, 2005·Pharmacology, Biochemistry, and Behavior·Fábio C CruzCleopatra S Planeta

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