Nicotine and extinction of fear conditioning.

Neuroscience
G A EliasT J Gould

Abstract

Despite known health risks, nicotine use remains high, especially in populations diagnosed with mental illnesses, including anxiety disorders and Post-Traumatic Stress Disorder (PTSD). Smoking in these populations may relate to the effects of nicotine on emotional memories. The current study examined the effects of nicotine administration on the extinction of conditioned fear memories. C57BL/6J mice were trained with two white noise conditioned stimulus (CS; 30 s, 85 dB)-foot shock (2 s, 0.57 mA) pairings. Extinction sessions consisted of six presentations of the CS (60 s) across multiple days. Mice were either tested in an AAA design, in which all stages occurred in the same context, or in an ABA design to identify if context changes alter extinction. Saline or nicotine was administered 5 min before training and/or extinction. In the AAA design, nicotine administration before training did not alter extinction. Nicotine administered prior to extinction sessions enhanced extinction and nicotine administered before training and extinction decreased extinction. In the ABA design, nicotine administered before extinction enhanced extinction and blocked context renewal of conditioned fear, while nicotine administered during training ...Continue Reading

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Citations

Jun 28, 2014·Neurochemical Research·J Alex Grizzell, Valentina Echeverria
Mar 13, 2012·Neuroscience and Biobehavioral Reviews·Adrie W Bruijnzeel
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May 28, 2019·Neuroscience and Biobehavioral Reviews·E R VelascoR Andero

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