PMID: 2497478Jan 1, 1989Paper

Nicotine and some related compounds: effects on schedule-controlled behaviour and discriminative properties in rats

Psychopharmacology
S R GoldbergH S Garcha

Abstract

Behavioural effects of d- and l-nicotine, d- and l-nornicotine and l-cotinine were studied in two paradigms. In experiment 1, rats responded under a multiple fixed-interval (FI) 5 min, fixed-ratio (FR) 20 schedule of food presentation. Aside from differences in potency and time course, l-nicotine and the stereoisomers of nornicotine produced qualitatively similar effects on rates of responding. With increasing doses of drugs, FI response rates first increased and then decreased, while FR response rates only decreased. In contrast, d-nicotine did not significantly increase FI response rates at lower doses, and only decreased FI and FR response rates at higher doses. At doses up to 100 mg/kg, cotinine produced only dose-dependent increases in FI response rates and had no effect on FR response rates. Rate-increasing effects of cotinine were not blocked by mecamylamine. In experiment 2, rats were trained to discriminate between l-nicotine (0.1 mg/kg SC) and saline (0.1 ml/kg SC) in a two-bar, operant conditioning procedure under a tandem variable-interval (VI) 1 min, FR 10 schedule of food presentation. Full generalization was obtained to d-nicotine and to l- and d-nornicotine. Generalization to cotinine occurred only with large do...Continue Reading

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Citations

Jan 1, 1995·Medicinal Research Reviews·I P StolermanM Shoaib
Oct 17, 2003·Archives of Pharmacal Research·Young-Yeop KohDong-Yoon Lim
Feb 22, 2005·Psychopharmacology·C NaylorI P Stolerman
Jan 1, 1989·Life Sciences·J M WitkinM J Kuhar
Jan 1, 1989·Psychoneuroendocrinology·O F Pomerleau, J Rosecrans
Apr 20, 2000·European Journal of Pharmacology·I P StolermanM Shoaib
Sep 25, 2002·Life Sciences·David H MalinAli Fattom
Apr 23, 2003·Life Sciences·Jerry J Buccafusco, Alvin V Terry
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·A R CaggiulaA F Sved
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·T A GreenM T Bardo
Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·D K HatsukamiR Bliss
Jun 6, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Paula L Vieira-BrockDiana G Wilkins
Oct 4, 2007·Behavioural Pharmacology·Thomas E Wooters, Michael T Bardo
Feb 22, 2012·Addiction Biology·Jeffrey W GrimmStefan Collins
Jun 28, 2014·Neurochemical Research·J Alex Grizzell, Valentina Echeverria
Feb 20, 2016·Psychopharmacology·Rajeev I DesaiJack Bergman
Jul 30, 2014·Neuroscience and Biobehavioral Reviews·Katharine A BrennanPenelope Truman
Nov 29, 2011·Behavioural Processes·Rick A BevinsSergios Charntikov
Feb 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Amy K GoodwinMerle G Paule
Jun 22, 2015·Drug and Alcohol Dependence·Andrew C HarrisMark G LeSage
Apr 5, 2008·Neurotoxicology and Teratology·K A JaremaR C MacPhail
Oct 2, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jenny L WileyKia J Jackson
Oct 25, 2017·Behavioural Pharmacology·Lindsay P SchwartzAlan Silberberg
May 23, 2018·The Journal of Pharmacology and Experimental Therapeutics·Sarah L WitheyRajeev I Desai
Sep 12, 2015·The Journal of Pharmacology and Experimental Therapeutics·Kelen C FreitasF Ivy Carroll

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