Nicotine as a signal for the presence or absence of sucrose reward: a Pavlovian drug appetitive conditioning preparation in rats

Psychopharmacology
Joyce BesheerRick A Bevins

Abstract

In Pavlovian conditioning research, nicotine is typically conceptualized as the unconditioned stimulus (US) that becomes associated with an exteroceptive conditioned stimulus (CS). This research has not explored the possibility that nicotine can also function as a CS. The present research examined whether nicotine served as a CS for the presence (CS+) or absence (CS-) of sucrose and started defining its specificity. Rats trained in the CS+ condition had nicotine (0.4 mg/kg, base) paired intermittently with brief access to sucrose. Intermixed were saline sessions without sucrose. Nicotine acquired the ability to evoke goal tracking. This conditioned response (CR) decreased across extinction sessions. The CR was sensitive to nicotine dose (ED(50)=0.113 mg/kg) and administration to testing interval; 0-min and 100-min delays produced no CR. The CS properties were specific to nicotine in that amphetamine and bupropion substitution was incomplete. Rats in the CS- condition received similar discrimination training except that sucrose was paired with saline. Nicotine also served as a CS-; the saline state CS+ acquired control of goal tracking. Mecamylamine, but not hexamethonium, blocked nicotine's ability to serve as a CS+ and CS-, in...Continue Reading

Citations

Jan 28, 2009·Behavioral Neuroscience·Jennifer E Murray, Rick A Bevins
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sergios CharntikovRick A Bevins
Feb 25, 2006·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jamie L WilkinsonRick A Bevins
Apr 12, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Darlene H Brunzell
Nov 9, 2007·Behavioural Pharmacology·Jennifer E Murray, Rick A Bevins
Jun 29, 2010·Addiction Biology·Jennifer E MurrayRick A Bevins
Feb 22, 2012·Addiction Biology·Jeffrey W GrimmStefan Collins
Mar 24, 2009·Journal of Psychopharmacology·Jamie L WilkinsonRick A Bevins
Oct 18, 2014·Behavioural Pharmacology·Robin McGovernWilliam C Griffin
Sep 18, 2014·Pharmacology, Biochemistry, and Behavior·Matthew I PalmatierDonita L Robinson
Dec 2, 2004·Experimental and Clinical Psychopharmacology·Joseph R Troisi, Chana Akins
Nov 29, 2011·Behavioural Processes·Rick A BevinsSergios Charntikov
Jul 11, 2014·ACS Chemical Neuroscience·Rick A Bevins, Joyce Besheer
Sep 22, 2009·Pharmacology, Biochemistry, and Behavior·S B Harrod, M Lee Van Horn
Sep 8, 2009·Drug and Alcohol Dependence·N M NeugebauerM T Bardo
May 5, 2007·Pharmacology, Biochemistry, and Behavior·Jennifer E MurrayRick A Bevins
Feb 16, 2007·Physiology & Behavior·Jamie L Wilkinson, Rick A Bevins
Mar 9, 2007·European Journal of Pharmacology·Jennifer E Murray, Rick A Bevins
Nov 10, 2013·Pharmacology, Biochemistry, and Behavior·Steven T Pittenger, Rick A Bevins
Feb 18, 2012·Drug and Alcohol Dependence·A Brianna SheppardMatthew I Palmatier
Oct 11, 2008·Behavioural Brain Research·Matthew I Palmatier, Rick A Bevins
Jan 18, 2005·Behavioral and Cognitive Neuroscience Reviews·Rick A Bevins, Matthew I Palmatier
Jan 4, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mandy Rita LeCocqNadia Chaudhri
Feb 15, 2017·Alcoholism, Clinical and Experimental Research·Aric C MadayagDonita L Robinson
Oct 2, 2020·Psychopharmacology·Christian MontanariNicholas W Gilpin
Mar 25, 2020·Pharmacological Reviews·M J MoerkeJ L Wilkerson

Related Concepts

Metazoa
Appetitive Behavior
Association Learning
Conditioned Reflex
Dose-Response Relationship, Drug
Extinction, Psychological
Generalization (Psychology)
Rewards
Sucrose
Rats, Holtzman

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