Nicotine concentrations with electronic cigarette use: effects of sex and flavor

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Cheryl A OnckenNausherwan A Burki

Abstract

This study examined overall changes in nicotine concentrations when using a popular e-cigarette and 18 mg/mL nicotine e-Juice, and it further explored effects of sex and flavorings on these concentrations. We recruited nontreatment-seeking smokers who were willing to try e-cigarettes for 2 weeks and abstain from cigarette smoking. Subjects were randomized to either menthol tobacco or non-menthol tobacco-flavored e-cigarette use for 7-10 days, and the next week they were crossed over to the other condition. On the last day of e-cigarette use of each flavor, subjects completed a laboratory session in which they used the e-cigarette for 5 min ad libitum. Nicotine concentrations were obtained 5 min before and 5, 10, 15, 20, and 30 min after the onset of e-cigarette use. Twenty subjects completed at least 1 monitoring session. Nicotine concentrations significantly increased from baseline to 5 min by 4 ng/mL at the first laboratory session (p < .01) and by 5.1 ng/mL at the second laboratory session (p < .01). Combining sessions, there were no main effects of sex or preferred flavor (based on smoking history) on changes in nicotine concentrations. After adding preferred flavor, sex, and visit order to the model, there was a significan...Continue Reading

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Citations

Jan 17, 2016·Annals of the New York Academy of Sciences·Alison BrelandThomas Eissenberg
Mar 24, 2017·Nature Reviews. Cardiology·Neal L Benowitz, Joseph B Fraiman
Sep 14, 2016·The Cochrane Database of Systematic Reviews·Jamie Hartmann-BoycePeter Hajek
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