Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: regulatory implications

Addiction
Maciej L GoniewiczHayden McRobbie

Abstract

Electronic cigarettes (EC) may have a potential for public health benefit as a safer alternative to smoking, but questions have been raised about whether EC should be licensed as a medicine, with accurate labelling of nicotine content. This study determined the nicotine content of the cartridges of the most popular EC brands in the United Kingdom and the nicotine levels they deliver in the vapour, and estimated the safety and consistency of nicotine delivery across batches of the same product as a proxy for quality control for individual brands and within the industry. We studied five UK brands (six products) with high internet popularity. Two samples of each brand were purchased 4 weeks apart, and analysed for nicotine content in the cartridges and nicotine delivery in vapour. The nicotine content of cartridges within the same batch varied by up to 12% relative standard deviation (RSD) and the mean difference between different batches of the same brand ranged from 1% [95% confidence interval (CI) = -5 to 7%] to 20% (95% CI=14-25%) for five brands and 31% (95% CI=21-39%) for the sixth. The puffing schedule used in this study vaporized 10-81% of the nicotine present in the cartridges. The nicotine delivery from 300 puffs ranged ...Continue Reading

References

Jan 20, 2000·Journal of the National Cancer Institute·M V DjordjevicE Zang
Jul 21, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Anna TrtchounianPrue Talbot
Dec 9, 2010·Tobacco Control·Anna Trtchounian, Prue Talbot
May 20, 2011·Addiction·Jean-François Etter, Chris Bullen
Apr 25, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Maciej L GoniewiczLeon Kosmider
May 25, 2013·Addiction·Jean-François EtterSofie Svensson
Jul 17, 2013·JAMA : the Journal of the American Medical Association·Neal L Benowitz, Maciej L Goniewicz
Jan 17, 2014·The Lancet. Respiratory Medicine·Peter HajekDerek Yach

❮ Previous
Next ❯

Citations

May 14, 2014·Circulation·Rachel GranaStanton A Glantz
Apr 16, 2014·Tobacco Control·Ling YangElizabeth L Durmowicz
May 9, 2014·The International Journal on Drug Policy·Laura WilliamsonAlfred Uhl
Sep 17, 2014·Head & Face Medicine·Ines WillershausenBrita Willershausen
Sep 3, 2014·Environmental Health Perspectives·Carrie Arnold
Jul 10, 2014·Journal of General Internal Medicine·Lori A Bastian, Cheryl Oncken
Dec 3, 2014·Preventive Medicine·Charlotta Pisinger, Martin Døssing
Mar 20, 2016·Talanta·D Gallart-MateuM de la Guardia
Jan 17, 2016·Chemistry : a European Journal·Diego García-GómezRenato Zenobi
Feb 3, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Margaret NolanDavid O Warner
Jan 17, 2016·Annals of the New York Academy of Sciences·Alison BrelandThomas Eissenberg
Feb 26, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Tomasz R Sosnowski, Katarzyna Kramek-Romanowska
Aug 27, 2015·Academic Pediatrics·Jane M GarbuttRobert C Strunk
Jan 27, 2015·Tobacco Induced Diseases·Jürgen HahnDirk W Lachenmeier
Sep 30, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael Hadjiargyrou, Regis J O'Keefe
Aug 5, 2015·Clinical Oral Investigations·Silvia SancilioViviana di Giacomo
May 7, 2014·Addiction·Sara C HitchmanLeonie S Brose
Apr 22, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sara C HitchmanAnn McNeill
Jun 6, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Todd PaganoRisa J Robinson
Jul 15, 2015·Chemical Research in Toxicology·Ahmad El-HellaniNajat A Saliba
May 23, 2015·International Journal of Pediatric Otorhinolaryngology·Sneh Biyani, Craig S Derkay
Mar 1, 2015·The International Journal on Drug Policy·Maciej L GoniewiczAndrzej Sobczak
Apr 25, 2015·The American Journal of Emergency Medicine·Frank LoVecchio, Olivia Zoph
May 2, 2015·Addictive Behaviors·Yong Hee LeeMaciej Lukasz Goniewicz
May 3, 2014·Tobacco Control·Rachel KornfieldSherry L Emery
Jun 22, 2014·Preventive Medicine·Ahmad Besaratinia, Stella Tommasi
Jun 9, 2015·PloS One·R J RobinsonK A Roundtree
Oct 23, 2015·Tobacco Control·Christine D CzoliDavid Hammond
Dec 17, 2014·Tobacco Control·Lauren K LempertStanton A Glantz
Jun 10, 2015·Tobacco Control·Catriona RookeAmanda Amos
May 12, 2016·Journal of Analytical Toxicology·Michelle R PeaceAlphonse Poklis
May 21, 2016·Environmental Research·Pablo OlmedoAna Rule
Aug 2, 2016·Toxicology·Mohammad Abul KaisarLuca Cucullo
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Maciej L GoniewiczNeal L Benowitz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.