Nicotine deprivation increases pain intensity, neurogenic inflammation, and mechanical hyperalgesia among daily tobacco smokers

Journal of Abnormal Psychology
Joseph W DitreMartin J De Vita

Abstract

An evolving reciprocal model posits that pain and tobacco smoking behavior interact in the manner of a positive feedback loop, resulting in greater pain and the maintenance of nicotine dependence. There is also reason to believe that abstaining from smoking may increase pain during the early stages of smoking cessation. The goal of this study was to test the effects of nicotine deprivation on experimental pain reactivity. Daily tobacco cigarette smokers (N = 165; 43% female) were randomized to either extended nicotine deprivation (12-24 hr smoking abstinence), minimal deprivation (2 hr smoking abstinence), or continued smoking conditions, prior to undergoing pain induction via topical capsaicin. As hypothesized, results indicated that extended deprivation (relative to continued smoking) increased capsaicin-induced pain intensity ratings, neurogenic inflammation, and mechanical hyperalgesia, thus implicating both central and peripheral mechanisms of action in the effects of smoking abstinence on pain reactivity. Pain intensity ratings were also positively correlated with nicotine withdrawal symptoms, and exploratory analyses suggest that pain sensitivity may increase with duration of smoking abstinence. Collectively, these findi...Continue Reading

Citations

Feb 29, 2020·CNS Drugs·Cynthia VladShadi Nahvi
Mar 11, 2020·Cephalalgia : an International Journal of Headache·Sabine Salhofer-PolanyiChristian Wöber
Mar 25, 2020·Pain·Lisa R LaRowe, Joseph W Ditre
Jul 1, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Joseph W DitreJessica M Powers
Jan 31, 2020·Regional Anesthesia and Pain Medicine·W Michael HootenM Hassan Murad
Jul 24, 2020·Pain·Lisa R LaRowe, Joseph W Ditre
Nov 30, 2018·Journal of Behavioral Medicine·Michael J ZvolenskyNatalia Peraza
Feb 6, 2020·The American Journal on Addictions·Lisa R LaRoweJoseph W Ditre
Dec 19, 2020·Translational Neuroscience·Lina GuoZongwang Zhang
May 30, 2020·Neuropharmacology·Elizabeth C Delery, Scott Edwards
Mar 25, 2021·European Journal of Pain : EJP·Charles QuesadaLuis Garcia-Larrea
Aug 31, 2021·Wiener klinische Wochenschrift·Megan LeeLori A Bastian

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