PMID: 6405438Jan 1, 1983Paper

Nicotine does not improve discrimination of brain stimulation reward by rats

Psychopharmacology
P B Clarke, R Kumar

Abstract

Rats were trained to shuttle between two selected ("ON") arms of a Y maze, to obtain electrical stimulation of the medial forebrain bundle. Each shuttle response was rewarded with a brief pulse train. Repetitive entries into the same "ON" arm were not rewarded, nor were entries made into the third ("OFF") arm. Every 67s, stimulation was made available from a different pair of arms. Test sessions lasted for 80 min, beginning immediately after SC injection. Undrugged subjects responded faster, and with a greater proportion of rewarded responses, the higher the stimulation current. In non-tolerant rats, nicotine (0-0.4 mg/kg) depressed responding and induced ataxia shortly after injection; from 40 min, nicotine increased low rates of responding but decreased high rates. All these effects were dose-dependent. Mecamylamine (2.0 mg/kg) prevented the initial depressant action. With repeated daily injections of nicotine (0.4 mg/kg), a marked stimulant action emerged which replaced the initial depressant action, and this was dose-dependent. However, responding was increased by nicotine even when brain stimulation was not available ("time-out"). In contrast, an additional "rate-free" index based on discrimination showed that nicotine did...Continue Reading

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Citations

Oct 15, 1989·Biochemical Pharmacology·B R MartinT J Martin
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·W A CorrigallK M Coen
Apr 1, 1992·Pharmacology, Biochemistry, and Behavior·D Huston-Lyons, C Kornetsky
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·G Tanda, S R Goldberg
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·A M Montgomery, A J Grottick
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·S S WatkinsA Markou
Nov 20, 1998·Behavioural Brain Research·M A BozarthR KuoLee
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiu LiuRussell E Poland
May 1, 1984·British Journal of Pharmacology·P B Clarke, R Kumar
Nov 1, 1983·British Journal of Pharmacology·P B Clarke, R Kumar
Aug 1, 1985·British Journal of Pharmacology·P B ClarkeL R Skirboll

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