Nicotine exerts an anti-inflammatory effect in a murine model of acute lung injury.

Inflammation
Jon G MableyPal Pacher

Abstract

Activation of the cholinergic anti-inflammatory pathway through direct activation of nicotinic acetylcholine receptors on immune cells can inhibit pro-inflammatory chemokine and cytokine release and thereby protect in a variety of inflammatory diseases. The aim of this study was to investigate whether nicotine treatment protected against acute lung inflammation. Mice challenged with intratracheal lipopolysaccharide (LPS, 50 μg) were treated with nicotine (0.2 or 0.4 mg/kg, sc). After 24 h, bronchoalveolar lavage fluid (BALF) was obtained to measure leukocyte infiltration, lung edema, and pro-inflammatory chemokine (MIP-1α, MIP-2, and eotaxin) and cytokine (IL-1, IL-6, and TNF-α) levels. Nicotine treatment reduced the LPS-mediated infiltration of leukocytes and edema as evidenced by decreased BALF inflammatory cells, myeloperoxidase, and protein. Nicotine also downregulated lung production of pro-inflammatory chemokines and cytokines. These data support the proposal that activation of the cholinergic anti-inflammatory pathway may represent a useful addition to the therapy of acute respiratory distress syndrome.

References

Jan 5, 1995·The New England Journal of Medicine·M H Kollef, D P Schuster
Jan 23, 1999·European Journal of Gastroenterology & Hepatology·R EliakimA Fich
Jul 29, 1999·Chest·R M StrieterT J Standiford
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·P BorronJ R Wright
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E AbrahamJ Arcaroli
Jan 31, 2002·American Journal of Respiratory and Critical Care Medicine·Lucas LiaudetCsaba Szabó
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·J G MableyC Szabó
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·J G MableyA L Salzman
Jan 1, 2004·American Journal of Respiratory and Critical Care Medicine·Marie-Renée BlanchetYvon Cormier
May 18, 2005·The Journal of Infectious Diseases·David J van WesterlooTom van der Poll
Jun 7, 2005·American Journal of Respiratory and Critical Care Medicine·Xinqi PengPaul M Hassoun
Aug 16, 2006·Seminars in Respiratory and Critical Care Medicine·Lorraine B Ware
Dec 21, 2006·Clinical and Experimental Immunology·X WitteboleS F Lowry
Feb 3, 2007·The Journal of Clinical Investigation·Kevin J Tracey
Apr 14, 2007·American Journal of Respiratory Cell and Molecular Biology·Xiao SuMichael A Matthay
May 1, 2007·World Journal of Gastroenterology : WJG·A Karban, R Eliakim
May 16, 2007·British Journal of Pharmacology·W J de Jonge, L Ulloa
Jun 29, 2007·Pharmacology & Therapeutics·Catherine R GwiltDuncan F Rogers
Dec 20, 2007·Critical Care Medicine·Stefan HoferMarkus A Weigand
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neerad C MishraMohan L Sopori
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mauricio Rosas-BallinaKevin J Tracey
Jan 1, 2009·Arthritis and Rheumatism·Marjolein A van MaanenPaul P Tak
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fu-Dong ShiRonald J Lukas

❮ Previous
Next ❯

Citations

Feb 8, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R B GonçalvesF H Nociti
Apr 21, 2012·American Journal of Epidemiology·Sadie PalmisanoMaria Feychting
Jan 25, 2013·Journal of Toxicologic Pathology·Masanao YokohiraKatsumi Imaida
Nov 14, 2013·BioMed Research International·Daniely Cornélio FavarinAlexandre de Paula Rogerio
May 28, 2013·BioMed Research International·Dur-Zong HsuMing-Yie Liu
Dec 8, 2014·Best Practice & Research. Clinical Rheumatology·F A KoopmanP P Tak
Jan 13, 2016·Journal of Cellular Physiology·Mariana Rodrigues Pereira, Paulo Emílio Corrêa Leite
Jul 15, 2016·Journal of Immunotoxicology·Saurabh PandeyAmitha K Hewavitharana
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Zarife N Özdemir-KumralBerrak Ç Yegen
Oct 9, 2016·Clinical and Experimental Pharmacology & Physiology·Dilek ÖzbeyliÖzgür Kasımay Çakır
Oct 7, 2017·Current Allergy and Asthma Reports·Phillip W Clapp, Ilona Jaspers
May 27, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yuan Xu, Lars-Olaf Cardell
Mar 12, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Ahmad Nazrun ShuidIsa Naina Mohamed
Oct 22, 2019·Clinical and Experimental Immunology·C E Valdez-MiramontesB Rivas-Santiago
Oct 13, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nathalia M PinheiroCarla M Prado
Aug 14, 2020·The FEBS Journal·Yousef TizabiMichael Aschner
Feb 1, 2019·BMC Medical Informatics and Decision Making·Guocai ChenW Jim Zheng
Jul 1, 2020·Frontiers in Immunology·Jesus Gonzalez-RubioAlberto Najera
Jan 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nathalia M PinheiroCarla M Prado
Jul 9, 2020·Therapeutic Advances in Chronic Disease·Konstantinos FarsalinosRaymond Niaura
Sep 13, 2012·Inflammation·Nie YingkunYu Huimin
Sep 16, 2018·Scientific Reports·Camila HirotsuMonica Levy Andersen
Oct 10, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·José Manuel Cóndor CapchaSamirah Abreu Gomes
Aug 30, 2020·Infection·Dominik WolffMichael Marschollek
Sep 13, 2020·International Journal of Molecular Sciences·Vivek K KashyapSubhash C Chauhan
Oct 15, 2020·International Journal of Environmental Research and Public Health·Jesus González-RubioAlberto Nájera
Oct 10, 2020·The Journal of Pharmacology and Experimental Therapeutics·Ali Ehsan SifatThomas J Abbruscato
Jun 24, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Peter G ShieldsMark D Wewers
Jan 28, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·George LagoumintzisKonstantinos Poulas
Oct 26, 2020·Addictive Behaviors·Amanda M RainesC Laurel Franklin
May 2, 2020·Toxicology Reports·Konstantinos FarsalinosKonstantinos Poulas
Mar 20, 2021·Tobacco Use Insights·Nadira Naznin Rakhi, Ritu Biswas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved