Nicotine exposure and the progression of chronic kidney disease: role of the α7-nicotinic acetylcholine receptor.

American Journal of Physiology. Renal Physiology
Gabriel RezonzewEdgar A Jaimes

Abstract

Clinical studies have established the role of cigarette smoking as a risk factor in the progression of chronic kidney disease (CKD). We have shown that nicotine promotes mesangial cell proliferation and hypertrophy via nonneuronal nicotinic acetylcholine receptors (nAChRs). The α7-nAChR is one of the most important subunits of the nAChRs. These studies were designed to test the hypothesis that nicotine worsens renal injury in rats with 5/6 nephrectomy (5/6Nx) and that the α7-nAChR subunit is required for these effects. We studied five different groups: Sham, 5/6Nx, 5/6Nx + nicotine (Nic; 100 μg/ml dry wt), 5/6Nx + Nic + α7-nAChR blocker methyllicaconitine (MLA; 3 mg·kg(-1)·day(-1) sq), and Sham + Nic. Blood pressure was measured by the tail-cuff method, and urine was collected for proteinuria. After 12 wk, the rats were euthanized and kidneys were collected. We observed expression of the α7-nAChR in the proximal and distal tubules. The administration of nicotine induced a small increase in blood pressure and resulted in cotinine levels similar to those found in the plasma of smokers. In 5/6Nx rats, the administration of nicotine significantly increased urinary protein excretion (onefold), worsened the glomerular injury score an...Continue Reading

References

Oct 1, 1992·Archives of Internal Medicine·M M Ward, S Studenski
Apr 1, 1968·Chemical Reviews·R L Stedman
May 28, 1993·Annals of the New York Academy of Sciences·W A Pryor, K Stone
Jan 18, 1996·The New England Journal of Medicine·D S CelermajerJ E Deanfield
Feb 15, 1996·Nature·G H LeeJ M Friedman
Sep 6, 2000·Nephron·S R Orth
Jan 10, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A A Eddy
Sep 15, 2001·The Tohoku Journal of Experimental Medicine·S R OrthE Ritz
Aug 22, 2002·The Journal of Clinical Investigation·Christopher HeeschenJohn P Cooke
May 9, 2003·American Journal of Physiology. Renal Physiology·Kumar SharmaStephen R Dunn
Jun 13, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·François CachatJean-Pierre Guignard
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Toyoshi InoguchiHajime Nawata
May 20, 2004·Journal of Exposure Analysis and Environmental Epidemiology·Joachim HeinrichChristine Schulz
Jul 13, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jesse RomanSusanne Roser-Page
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hye Sun ParkYun Soo Bae
Sep 2, 2005·The Journal of Biological Chemistry·Yves GorinHanna E Abboud
Oct 14, 2005·Kidney International·Edgar A JaimesLeopoldo Raij
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric CharpantierChristian Fuhrer
Jul 25, 2006·The Journal of Clinical Investigation·Piyali DasguptaSrikumar Chellappan
Aug 22, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Edgar A JaimesLeopoldo Raij
Jan 4, 2007·American Journal of Physiology. Renal Physiology·You-Lin TainChris Baylis
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause
May 25, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marcello SolinasSteven R Goldberg
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seddigheh Razani-BoroujerdiMohan L Sopori
Jun 17, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Chao-Yin ChenAnn C Bonham
Sep 5, 2008·Kidney International·Yaeko MotoyoshiIekuni Ichikawa
Oct 14, 2008·American Journal of Nephrology·Edgar A JaimesLeopoldo Raij
Aug 6, 2010·American Journal of Physiology. Renal Physiology·Ping HuaEdgar A Jaimes

❮ Previous
Next ❯

Citations

Sep 23, 2014·Iranian Red Crescent Medical Journal·Hasan PahangAriane Sadr Nabavi
Apr 22, 2015·The Journal of Urology·Neel H PatelEric C Kauffman
Apr 17, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Kendal JensenShannon S Glaser
Aug 16, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Varun Parkash SinghAmteshwar Singh Jaggi
Jun 4, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nora FranceschiniJianwen Cai
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Zarife N Özdemir-KumralBerrak Ç Yegen
Mar 31, 2016·PloS One·Chang Seong KimSoo Wan Kim
May 17, 2017·Geriatrics & Gerontology International·Andrea CorsonelloRaffaele Antonelli-Incalzi
Jan 25, 2018·American Journal of Physiology. Renal Physiology·Fernanda Oliveira CoelhoLucia Andrade
Jul 1, 2017·Pediatric Research·Istvan AranyMehul Dixit
Oct 1, 2015·Pharmacological Reviews·Daniel BertrandDiana Donnelly-Roberts
Dec 17, 2019·American Journal of Physiology. Renal Physiology·S RangarajanE A Jaimes
May 20, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Luan D TruongGabriela E Garcia
Dec 14, 2019·Aging·Gurinder Bir SinghKrishna M Boini
Sep 25, 2020·American Journal of Hypertension·Robert C KaplanNora Franceschini
Jan 19, 2021·American Journal of Physiology. Renal Physiology·Edgar A JaimesLeopoldo Raij
May 20, 2021·World Journal of Gastroenterology : WJG·Rajiv HedaSanjaya K Satapathy
Sep 10, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Santosh KumarJohn Bissler
Oct 21, 2021·The Korean Journal of Internal Medicine·Yu Ji JiangCan Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.