Nicotine exposure in vivo induces long-lasting enhancement of NMDA receptor-mediated currents in the hippocampus

The European Journal of Neuroscience
Yoshihiko YamazakiKatumi Sumikawa

Abstract

The use of nicotine via cigarette smoking forms long-lasting memories that are recalled in response to environmental cues associated with previous nicotine use. However, the changes in brain memory systems that underlie these long-lasting memories are not well understood. The N-methyl-D-aspartate receptor (NMDAR) is critical for long-lasting modifications of synapses. Here we show that in vivo nicotine exposure induces the enhancement of NR2B-containing NMDAR-mediated currents in the hippocampus, a brain region associated with the formation of memories. This nicotine effect is maintained during continued nicotine exposure and is accompanied by increased tyrosine phosphorylation of NR2B. Furthermore, long-term potentiation (LTP), which is considered to be a cellular substrate of learning and memory, induced in nicotine-exposed hippocampi contains a protein synthesis-independent long-lasting component. An NR2B-selective antagonist blocks a long-lasting component of LTP, but not LTP. These results suggest that exposure to nicotine provides conditions that promote the induction of long-lasting modifications of synapses, which may be involved in the formation of memories involving nicotine use.

References

May 1, 1992·Science·J J Kim, M S Fanselow
Feb 1, 1997·Trends in Neurosciences·S Wonnacott
Dec 24, 1997·The Journal of Physiology·S Jones, J L Yakel
Jul 2, 1998·Journal of Neurochemistry·Y IwasakiS Koizumi
Sep 2, 1998·Psychopharmacology·E D Levin, B B Simon
Sep 15, 1999·Nature·Y P TangJ Z Tsien
Jun 9, 2000·Annual Review of Physiology·M Sheng, D T Pak
Oct 5, 2001·Nature Reviews. Neuroscience·S E Hyman, R C Malenka
Apr 24, 2002·Neuron·Kenneth R Tovar, Gary L Westbrook
Jul 20, 2002·Neuropharmacology·Angela M ThompsonJohn J Wagner
Aug 6, 2002·Neuron·Andres Barria, Roberto Malinow
Feb 1, 2003·Neurobiology of Learning and Memory·T W Robbins, B J Everitt
Feb 1, 2003·Neurobiology of Learning and Memory·Eric J Nestler
Dec 13, 2003·Cell Calcium·Sergio Fucile
Mar 23, 2004·Nature Reviews. Neuroscience·Michael W Salter, Lorraine V Kalia
May 20, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lavina J FaleiroJulie A Kauer
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie L BorglandAntonello Bonci
Oct 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rita A FuchsRonald E See
Mar 15, 2005·Psychopharmacology·Bernard Le Foll, Steven R Goldberg

❮ Previous
Next ❯

Citations

Sep 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hong LinDavid R Lynch
Dec 24, 2013·Molecular Brain·Shupeng LiFang Liu
Jul 28, 2011·Reviews in the Neurosciences·Robin A J Lester
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rachel E PentonRobin A J Lester
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Masaru IshibashiKatumi Sumikawa
Jan 20, 2007·Neurotoxicology and Teratology·Oksana O PolesskayaRobert F Smith
Jul 15, 2015·The International Journal of Neuropsychopharmacology·Paula L Vieira-BrockAnnette E Fleckenstein
Mar 18, 2009·The European Journal of Neuroscience·James Edgar McCutcheon, Michela Marinelli
Dec 13, 2006·The European Journal of Neuroscience·Yoshihiko YamazakiKatumi Sumikawa
Sep 15, 2015·Molecular and Cellular Neurosciences·Jing-Jing DuanDarwin K Berg
Aug 21, 2007·Biochemical Pharmacology·Justin T Gass, M Foster Olive
Apr 20, 2013·Neuropharmacology·Yan-You HuangAmir Levine
May 4, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jianxun XiaJeff A Beeler
Sep 4, 2010·Journal of Clinical Psychopharmacology·Louise DuludeVerner J Knott
Jul 16, 2010·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yoshihiko Yamazaki
Nov 3, 2016·The Mental Health Clinician·Robert W Schmidt, Meghan L Thompson
Apr 4, 2021·Brain Sciences·Yosef Avchalumov, Chitra D Mandyam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.