Nicotine increases alcohol self-administration in male rats via a μ-opioid mechanism within the mesolimbic pathway.

British Journal of Pharmacology
E DomiM Heilig

Abstract

Alcohol and nicotine use disorders are commonly comorbid. Both alcohol and nicotine can activate opioid systems in reward-related brain regions, leading to adaptive changes in opioid signalling upon chronic exposure. The potential role of these adaptations for comorbidity is presently unknown. Here, we examined the contribution of μ and κ-opioid receptors to nicotine-induced escalation of alcohol self-administration in rats. Chronic nicotine was tested on alcohol self-administration and motivation to obtain alcohol. We then tested the effect of the κ antagonist CERC-501 and the preferential μ receptor antagonist naltrexone on basal and nicotine-escalated alcohol self-administration. To probe μ or κ receptor adaptations, receptor binding and G-protein coupling assays were performed in reward-related brain regions. Finally, dopaminergic activity in response to alcohol was examined, using phosphorylation of DARPP-32 in nucleus accumbens as a biomarker. Nicotine robustly induced escalation of alcohol self-administration and motivation to obtain alcohol. This was blocked by naltrexone but not by CERC-501. Escalation of alcohol self-administration was associated with decreased DAMGO-stimulated μ receptor signalling in the ventral teg...Continue Reading

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Citations

Jan 23, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Ana DomiEsi Domi
Mar 12, 2021·Journal of Neurochemistry·Esi DomiEric Augier

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Methods Mentioned

BETA
saturation binding

Key Resources (RRID) Mentioned

AB_2797914
AB_823479
AB_162543
SCR_003070
SCR_014213

Software Mentioned

MCID
Stat Soft
MCID Image Analysis for
ARRIVE
STATISTICA
ImageJ

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