Nicotine increases chemoreflex sensitivity to hypoxia in non-smokers

Journal of Hypertension
Jean-François ArgachaPhilippe van de Borne

Abstract

The peripheral chemoreflex contributes to cardiovascular regulation and represents the first line of defence against hypoxia. The effects of nicotine on chemoreflex regulation in non-smoking humans are unknown. We conducted a prospective, randomized, crossover, and placebo-controlled study in 20 male non-smokers to test the hypothesis that nicotine increases chemoreflex sensitivity. The effects of two intakes of 2 mg nicotine tabs and placebo on sympathetic nerve activity to muscle circulation (muscle sympathetic nerve activity; MSNA), minute ventilation (Ve), blood pressure and heart rate were assessed during normoxia, moderate isocapnic hypoxia, hyperoxic hypercapnia and an isometric handgrip in 10 subjects. Maximal end-expiratory apnoeas were performed at baseline and at the end of the fifth minute of hypoxia. In a second experimental setting, we studied the ventilatory response to a more marked isocapnic hypoxia in 10 other volunteers. Mean MSNA and Ve were not modified by nicotine during the 5 min of normoxia or moderate hypoxia. In the presence of nicotine MSNA was related to oxygen desaturation (P < 0.01). The sympathoexcitatory effects of nicotine became especially evident when apnoeas achieved oxygen saturations less t...Continue Reading

References

Feb 14, 1979·Pflügers Archiv : European journal of physiology·N B Dev, H H Loeschcke
Nov 1, 1977·The Journal of Physiology·G Sundlöf, B G Wallin
Dec 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S A SahnJ V Weil
Sep 1, 1975·Journal of Applied Physiology·D HeistadP G Schmid
Jun 1, 1991·The Journal of Clinical Investigation·V K SomersF M Abboud
Jul 1, 1990·Circulation Research·D R SealsJ A Dempsey
May 1, 1989·Journal of Applied Physiology·L Y LeeJ C Coleridge
Jun 1, 1989·Respiration Physiology·Y R KouL Y Lee
Jul 1, 1985·Journal of Applied Physiology·L Y LeeD T Frazier
Jan 1, 1982·Pharmacology & Therapeutics·C Su
Sep 1, 1980·International Journal of Dermatology·L Cohen
Jul 31, 1995·Neuroreport·R G RobertsJ Pennefather
Nov 1, 1994·Journal of Applied Physiology·J C HardyU Leuenberger
Oct 1, 1994·Physiological Reviews·C GonzalezR Rigual
Mar 1, 1994·Annals of Internal Medicine·K M HlaJ Dempsey
Jun 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J Fagius, B G Wallin
Jan 15, 1997·The Journal of Physiology·L L DassoR D Vaughan-Jones
Jan 1, 1997·Cardiovascular Drugs and Therapy·M Haass, W Kübler
Mar 27, 1998·Chest·B ChaudharyB Akhtar
Jul 29, 1998·Circulation·P van de BorneV K Somers
Dec 5, 1998·Brain Research·M ShirahataR S Fitzgerald
Jun 3, 1999·Environmental Health Perspectives·N L Benowitz
Apr 25, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·C J SmithS B Sears
Feb 17, 2001·The Journal of Physiology·E H VidrukG S Mitchell
Apr 11, 2001·European Journal of Clinical Pharmacology·L Molander, E Lunell
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Terry YoungDaniel J Gottlieb
Aug 17, 2002·Journal of Applied Physiology·John R Halliwill, Christopher T Minson
Nov 12, 2002·Respiratory Physiology & Neurobiology·Ricardo FernándezPatricio Zapata
Mar 1, 2003·Acta Physiologica Scandinavica·T KaraV K Somers
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Sonia Velez-RoaPhilippe van de Borne
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·C L Gentry, R J Lukas
Oct 28, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jae H ChoiKenneth R Strahs
May 25, 2005·Circulation·Joaquin Barnoya, Stanton A Glantz
Dec 7, 2005·Journal of Hypertension·J P BaguetJ M Mallion
Jan 31, 2006·British Journal of Pharmacology·Sílvia V Conde, Emília C Monteiro

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Citations

May 24, 2008·Acta Physiologica·J F ArgachaP van de Borne
May 4, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Indu TanejaJulian M Stewart
May 9, 2014·Sleep Disorders·Jennifer SchwartzChris G Richardson
Feb 28, 2015·Military Medical Research·Pan SongLan Huang
Apr 30, 2008·Hypertension·Martin Hausberg, Virend K Somers
Sep 23, 2008·Journal of Cardiovascular Pharmacology·J F ArgachaG Berkenboom
May 1, 2010·Blood Pressure·Dagmara HeringKrzysztof Narkiewicz
Jul 21, 2017·International Journal of Environmental Research and Public Health·Xianglong XuYong Zhao
Oct 27, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Aurélien WautersJean-François Argacha

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