Nicotine-induced conditioned taste aversion in the rat: effects of ethanol

European Journal of Pharmacology
Agnieszka KorkoszP Bienkowski

Abstract

It has been shown that small doses of ethanol antagonise the discriminative stimulus properties of nicotine in the rat. The aim of the present study was to evaluate whether ethanol could antagonise the aversive stimulus effects of nicotine. Wistar rats were trained to associate nicotine injections with a novel tasting fluid (0.1% saccharin) in the conditioned taste aversion procedure. Nicotine (0.3 mg/kg, s.c.) was injected 5 min after the end of a 20-min exposure to the saccharin solution. Ethanol (0.25-0.5 g/kg, i.p.) was administered 5 or 50 min before nicotine. In general, ethanol did not inhibit nicotine-induced conditioned taste aversion. Contrary to the findings in drug discrimination studies, a slight but significant enhancement of nicotine-induced taste aversion conditioning was observed after ethanol pre-treatment. Blood ethanol levels were measured in a separate group of rats. Maximal blood ethanol levels after i.p. administration of 0.25 or 0.5 g/kg ethanol exceeded 20 and 80 mg%, respectively. Concluding, the present results may indicate that ethanol does not attenuate nicotine-induced conditioned taste aversion in the rat.

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Citations

Jan 22, 2008·Psychopharmacology·Jennifer A RinkerAnthony L Riley
Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hao ChenQingling Wu
Dec 20, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Elizabeth RalevskiIsmene Petrakis
Jun 7, 2007·Behavioural Pharmacology·Ami Cohen, Aaron Ettenberg
Dec 10, 2014·The American Journal of Drug and Alcohol Abuse·Tanseli NesilSakire Pogun
Feb 24, 2009·Neuroscience·E H HagenP Hammerstein
Apr 23, 2013·Fundamental & Clinical Pharmacology·Manish Manohar AglaweNandkishor Ramdas Kotagale
Jun 5, 2020·Neuropharmacology·Theresa Patten, Mariella De Biasi

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