Nicotine infusion into rat ventromedial nuclei and effects on monoaminergic system

Neuroreport
Eduardo J B RamosAlessandro Laviano

Abstract

Nicotine increases satiety and reduces food intake (FI). We hypothesize that nicotine influences FI via alteration of serotonin (5HT) and dopamine (DA) concentration in ventromedial nucleus (VMN) and lateral hypothalamic area (LHA). Microdialysis cannulas were implanted into ipsilateral VMN and contralateral LHA. Nicotine or vehicle was infused for 60 min into VMN of overnight food-deprived rats, followed by ad lib food for 40 min. Hypothalamic changes in 5HT and DA concentrations were measured every 20 min. Intra-VMN nicotine induced a long-lasting increase in 5HT concentration and an increase in DA for a short duration in the VMN, associated with an increase in 5HT in the LHA. Our data suggest that the nicotine-induced hypophagia correlates with VMN and LHA monoaminergic changes.

References

Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·Z J YangG Miyata
Oct 31, 2000·Nutrition·M M MeguidF Rossi-Fanelli
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T SatoL Zhang
Nov 19, 2002·Journal of Neurobiology·Young-Hwan JoLorna W Role
Aug 23, 2003·Endocrinology·Jeffrey M Zigman, Joel K Elmquist

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Citations

Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Alessandro LavianoFilippo Rossi Fanelli
Dec 29, 2009·Pharmacology, Biochemistry, and Behavior·L L BellingerP R Kramer
Jul 28, 2007·Life Sciences·Phillip R KramerLarry L Bellinger
Apr 20, 2007·Developmental Neurobiology·L Z Huang, U H Winzer-Serhan
Aug 21, 2008·American Journal of Physiology. Endocrinology and Metabolism·Alessandro LavianoMarilia Seelaender

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