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Nicotine inhibits palatal fusion and modulates nicotinic receptors and the PI-3 kinase pathway in medial edge epithelia

Orthodontics & Craniofacial Research

Sep 10, 2003

Pei Kang, Kathy K H Svoboda

Abstract

To analyze the effects of nicotine on palatal fusion inhibition in vitro and determine if nicotine modulated transforming growth factor beta3 or phosphatidylinositol-3 kinase signaling. A second objective was to determine the localization and regulation of nicotinic receptors in the med...read more

Mentioned in this Paper

Embryo
Establishment and Maintenance of Localization
Biochemical Pathway
Transforming Growth Factor beta
Phosphatidylinositol 3-Kinases
Organ Culture Techniques
Cleft Palate, Isolated
Protein kinase B gamma
Immunocytochemistry
Transforming growth factor beta3
Paper Details
References
  • References17
  • Citations15
12
  • References17
  • Citations15
12

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Nicotine inhibits palatal fusion and modulates nicotinic receptors and the PI-3 kinase pathway in medial edge epithelia

Orthodontics & Craniofacial Research

Sep 10, 2003

Pei Kang, Kathy K H Svoboda

PMID: 12962196

DOI: 10.1034/j.1600-0544.2003.02236.x

Abstract

To analyze the effects of nicotine on palatal fusion inhibition in vitro and determine if nicotine modulated transforming growth factor beta3 or phosphatidylinositol-3 kinase signaling. A second objective was to determine the localization and regulation of nicotinic receptors in the med...read more

Mentioned in this Paper

Embryo
Establishment and Maintenance of Localization
Biochemical Pathway
Transforming Growth Factor beta
Phosphatidylinositol 3-Kinases
Organ Culture Techniques
Cleft Palate, Isolated
Protein kinase B gamma
Immunocytochemistry
Transforming growth factor beta3

Feeds With Similar Papers

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

PI3K/AKT/mTOR Pathway

The PI3K/AKT/mTOR signal transduction pathway is crucial for cell cycle, thus directly regulates cell proliferation, longevity, and cancer. Here is the latest research on this intracellular signaling pathway.

Related Papers

Developmental Dynamics : an Official Publication of the American Association of Anatomists

TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion

Developmental Dynamics : an Official Publication of the American Association of AnatomistsJune 20, 2003
Xiao-Mei CuiCharles F Shuler
Developmental Dynamics : an Official Publication of the American Association of Anatomists

PI-3 kinase activity is required for epithelial-mesenchymal transformation during palate fusion

Developmental Dynamics : an Official Publication of the American Association of AnatomistsNovember 2, 2002
Pei Kang, Kathy K H Svoboda
Paper Details
References
  • References17
  • Citations15
12
  • References17
  • Citations15
12

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