Nicotine involved in periodontal disease through influence on cytokine levels

FEMS Immunology and Medical Microbiology
Asako MakinoTetsuo Kato

Abstract

Periodontal disease, for which smoking is a known risk factor, is infectious, and is associated with oral biofilm. Cytokines mediate and regulate immune and inflammatory responses. Lipopolysaccharide produced by periodontopathic bacteria plays a role in the progression of periodontitis. The effect of nicotine on cytokine production in mice was evaluated in this study. Nicotine (10 or 200 microg mouse(-1)) was administered intraperitoneally to 4-week-old female BALB/c mice, once a day, for 49 days. Control mice received injections of phosphate-buffered saline. Blood was collected from all mice and serum IL-6, IL-10, tumor necrosis factor (TNF)-alpha and IFN-gamma levels were measured by an enzyme-linked immunosorbent assay on the 42nd day. IL-6, IL-10 and IFN-gamma levels in the nicotine-treated mice were higher than those in the control mice. However, no differences were found in TNF-alpha levels between nicotine-treated and control mice. Lipopolysaccharide (20 microg mouse(-1)) purified from Aggregatibacter actinomycetemcomitans (formerly Actinobacillus actinomycetemcomitans) Y4 was administered intraperitoneally on the 49th day. A rapid increase in TNF-alpha was observed in the control mice at 2 h after administration of lipo...Continue Reading

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Citations

Jun 21, 2012·Journal of Periodontal Research·K CogoF C Groppo
Aug 29, 2009·Archives of Oral Biology·Karina CogoFrancisco Carlos Groppo
Jul 7, 2009·The American Journal of Cardiology·Vincent E FriedewaldUNKNOWN Journal of Periodontology
May 2, 2015·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Christian KirschneckPiero Römer
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Feb 18, 2010·Journal of Dental Research·W ZhangL J Windsor

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