Nicotine potentiation of morphine-induced catalepsy in mice

Pharmacology, Biochemistry, and Behavior
Mohammad-Reza ZarrindastMahshid Shafizadeh

Abstract

In the present study, effects of nicotine on catalepsy induced by morphine in mice have been investigated. Morphine but not nicotine induced a dose-dependent catalepsy. The response of morphine was potentiated by nicotine. Intraperitoneal administration of atropine, naloxone, mecamylamine, and hexamethonium to mice reduced catalepsy induced by a combination of morphine with nicotine. Intracerebroventricular injection of atropine, hexamethonium, and naloxone also decreased catalepsy induced by morphine plus nicotine. Intraperitoneal administration of atropine, but not intraperitoneal or intracerebroventricular injection of hexamethonium, decreased the effect of a single dose of morphine. It was concluded that morphine catalepsy can be elicited by opioid and cholinergic receptors, and the potentiation of morphine induced by nicotine may also be mediated through cholinergic receptor mechanisms.

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Oct 20, 2006·European Journal of Pharmacology·Mohammad-Reza Zarrindast, Sanaz Mohajeri
Apr 29, 2008·Neurobiology of Learning and Memory·Ameneh RezayofMohammad-Reza Zarrindast
Dec 3, 2011·Pharmacology, Biochemistry, and Behavior·Mohammad Reza ZarrindastMohaddeseh Ebrahimi-Ghiri
May 28, 2011·Journal of Psychopharmacology·Ronak AzizbeigiMohammad Reza Zarrindast
Mar 21, 2017·The Journal of Clinical Investigation·Jin XuYing-Xian Pan
May 19, 2021·Psychopharmacology·Ilya D IonovNicholas N Severtsev

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