Nicotine preference in smokers as a function of smoking abstinence

Pharmacology, Biochemistry, and Behavior
K A PerkinsA Caggiula

Abstract

Overnight smoking abstinence increases desire to smoke and intensity of smoking behavior in smokers, but it is not completely clear that this reflects an increase in reinforcement from the psychoactive effects of nicotine per se. We examined choice of nicotine vs. placebo via nasal spray (Study 1) and nicotine vs. nonnicotine cigarette puffs (Study 2) in separate groups of smokers during each of two sessions, following overnight abstinence vs. no abstinence. In each study, subjects followed a forced choice procedure in which they were instructed to self-administer six sprays/puffs from between the two nasal sprays/cigarettes every 15 min for 2 h following initial exposure to each. In Study 1, choice of nicotine spray (1.5 micrograms/kg per spray) increased significantly following abstinence vs. no abstinence (47 +/- 6% vs. 34 +/- 5%, respectively, p < 0.05). This shift in choice was more pronounced in the subset of smokers (choosers, n = 9 out of 24) who selected nicotine on more than 50% of choices on the abstinent day. Choosers exhibited greater responses to initial nicotine exposure on positive (e.g., pleasant, vigor) but not aversive (e.g., jittery, uneasy) subjective measures, suggesting that greater positive reinforcement...Continue Reading

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Citations

Sep 16, 2005·Psychopharmacology·Kenneth A PerkinsCaryn Lerman
Feb 19, 2005·Psychopharmacology·Julie A BlendyCaryn Lerman
Jul 8, 2008·Psychopharmacology·Kenneth A PerkinsAnnette S Wilson
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·A R CaggiulaA F Sved
Jul 30, 2008·The Behavioral and Brain Sciences·A David RedishAdam Johnson
Jul 2, 2002·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Kenneth A PerkinsAnnette S Wilson
Dec 22, 2005·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Bethea A KleykampThomas Eissenberg
Dec 22, 2005·Experimental and Clinical Psychopharmacology·Kenneth A PerkinsAnnette S Wilson
May 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mehmet SofuogluMarc Mooney
Jun 13, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heather G Fulton, Sean P Barrett
Aug 9, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·David Kalman, Stevens S Smith
Jul 28, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ovide F PomerleauErik J Sirevaag
Mar 15, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·James MacKillopRay S Niaura
Aug 12, 2008·Behavioural Pharmacology·Kenneth A PerkinsNeal L Benowitz
Nov 20, 2013·Harm Reduction Journal·Reuven Dar, Hanan Frenk
Oct 6, 2005·Psychopharmacology·Bernard Le Foll, Steven R Goldberg
Oct 12, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jennifer W TideyEmily M H Xavier
Sep 12, 2009·Psychoneuroendocrinology·Liana FattoreWalter Fratta
Apr 3, 2016·Psychopharmacology·Kenneth A PerkinsEric C Donny
Jun 13, 2015·Tobacco Control·Hillel R AlpertGregory N Connolly
Jul 6, 2005·Pharmacology, Biochemistry, and Behavior·Nasir H Naqvi, Antoine Bechara
Dec 21, 2010·Journal of Psychopharmacology·Theodora DukaDavid N Stephens
Jul 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yasmin ZakiniaeizKelly P Cosgrove
Dec 5, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth A Perkins, Joshua L Karelitz
Mar 26, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth A PerkinsEric C Donny
Dec 24, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth A Perkins
Mar 30, 2020·Psychopharmacology·Kenneth A Perkins, Joshua L Karelitz
Mar 30, 2020·Neuropharmacology·Mohammed Shoaib, Kenneth A Perkins

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