Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats

The Journal of Pharmacology and Experimental Therapeutics
Tanuja BordiaMaryka Quik

Abstract

Antipsychotics are an important class of drugs for the management of schizophrenia and other psychotic disorders. They act by blocking dopamine receptors; however, because these receptors are present throughout the brain, prolonged antipsychotic use also leads to serious side effects. These include tardive dyskinesia, repetitive abnormal involuntary movements of the face and limbs for which there is little treatment. In this study, we investigated whether nicotine administration could reduce tardive dyskinesia because nicotine attenuates other drug-induced abnormal movements. We used a well established model of tardive dyskinesia in which rats injected with the commonly used antipsychotic haloperidol develop vacuous chewing movements (VCMs) that resemble human orofacial dyskinesias. Rats were first administered nicotine (minipump; 2 mg/kg per day). Two weeks later, they were given haloperidol (1 mg/kg s.c.) once daily. Nicotine treatment reduced haloperidol-induced VCMs by ∼20% after 5 weeks, with a significant ∼60% decline after 13 weeks. There was no worsening of haloperidol-induced catalepsy. To understand the molecular basis for this improvement, we measured the striatal dopamine transporter and nicotinic acetylcholine rece...Continue Reading

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Citations

Jan 31, 2013·Experimental Neurology·Nicolas MorinThérèse Di Paolo
May 20, 2014·Pharmacology & Therapeutics·Maryka QuikTanuja Bordia
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Related Concepts

Nicotinic receptor alpha4beta2
Alpha6beta2 nicotinic acetylcholine receptor, rat
Metazoa
Waxy Flexibility
Lentiform Nucleus Structure
Dyskinesia, Medication-Induced
Haldol
Etat Marbre
Nicotinic Receptors
Antipsychotic Effect

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