PMID: 2119849Jun 18, 1990Paper

Nicotine releases stereoselectively and Ca2(+)-dependently endogenous 3,4-dihydroxyphenylalanine from rat striatal slices

Brain Research
Y MisuT Kubo

Abstract

In superfused slices of rat striatum, nicotine-evoked release of endogenous 3,4-dihydroxyphenylalanine (DOPA) was studied in comparison with that of dopamine (DA). (+/-)-Nicotine (0.1-10 microM) constantly and repetitively released DOPA and DA over a similar time course in a concentration-dependent manner. The ratio of DOPA and DA evoked was approximately 1:2-3. The turnover rate of DOPA was about 300 times higher compared to DA. (+/-)-Nicotine (10 microM)-induced DOPA release was mecamylamine (20 microM)-sensitive, Ca2(+)-dependent and tetrodotoxin (0.3 microM)-insensitive. The (+)-isomer induced no DOPA release. These characteristics of DOPA release were almost the same as those of DA. Nicotine evokes endogenous DOPA via nicotinic cholinergic receptors in a manner similar to the transmitter DA. These findings further support a probable role of DOPA as a neuroactive substance in the rat central nervous system.

References

Dec 19, 1988·Neuroscience Letters·H OkamuraM Geffard
Jan 1, 1982·Medicinal Research Reviews·M D Aceto, B R Martin
Jan 1, 1982·Pharmacology & Therapeutics·D J Balfour
Nov 7, 1980·Science·C Romano, A Goldstein

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Citations

May 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·J Opacka-Juffry, D J Brooks
Nov 1, 1995·Neuropharmacology·L SoliakovS Wonnacott
Apr 1, 1993·Trends in Pharmacological Sciences·Y Misu, Y Goshima
Sep 1, 1995·Neuroscience Research·Y MisuY Goshima
Aug 1, 1996·Progress in Neurobiology·Y MisuH Okamura
Aug 25, 1992·Biochimica Et Biophysica Acta·A Slominski, D Pruski
Feb 1, 2003·Pharmacology & Therapeutics·Yoshimi MisuYoshio Goshima
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P A RosenbergE Aizenman
Jul 9, 2016·Progress in Neurobiology·Philippe De DeurwaerdèreMark J Millan

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