PMID: 2501813Jan 1, 1989Paper

Nicotine replacement: ten-week effects on tobacco withdrawal symptoms

Psychopharmacology
J Gross, M L Stitzer

Abstract

This study examined the long-term effects of nicotine replacement on tobacco withdrawal symptoms. Smokers (N = 40 community volunteers) maintained biologically validated smoking abstinence under closely monitored conditions while chewing 2 mg nicotine gum (Nicorette; average of 6.9 pieces per day) or placebo gum during the first 10 weeks following smoking cessation. During the first postcessation week symptoms of irritability, anxiety, impatience, restlessness, excessive hunger, difficulty concentrating, drowsiness, sleep disturbance and tobacco craving intensity were significantly lower in active as compared with placebo nicotine gum subjects. Symptoms of psychological distress including irritability, anxiety and impatience declined over time in placebo subjects and were suppressed by replacement therapy below placebo treatment levels only during the first 4-5 weeks after smoking cessation. On other items, most notably increased appetite and excessive eating, stable between-group differences persisted over the entire 10-week trial. The data suggest that use of active gum beyond the first 5 weeks post-cessation may be inconsequential as far as suppression of certain key symptoms of psychological disturbance is concerned, but mo...Continue Reading

References

Oct 20, 1976·Psychopharmacology·S M Shiffman, M E Jarvik
Jan 1, 1988·Psychopharmacology·R West, M A Russell
Jan 1, 1988·Psychopharmacology·R West, N Schneider
Jan 1, 1987·British Journal of Addiction·L T Kozlowski, D A Wilkinson
Apr 1, 1987·British Journal of Addiction·R West, N Schneider
Jan 1, 1987·Addictive Behaviors·K O Fagerstrom
Mar 1, 1986·Archives of General Psychiatry·J R Hughes, D Hatsukami
Jan 1, 1985·Addictive Behaviors·K M CummingsL J Emrich
Jan 1, 1984·Journal of Psychosomatic Research·R J West
Jan 1, 1984·Psychopharmacology·J R HughesA Luknic
Jan 1, 1984·Psychopharmacology·D K HatsukamiD Svikis
Jan 1, 1984·Addictive Behaviors·N G SchneiderA B Forsythe
Aug 21, 1982·British Medical Journal·M J JarvisC Feyerabend
Jan 1, 1982·Psychopharmacology·R M Gilbert, M A Pope
Feb 1, 1982·The American Journal of Clinical Nutrition·J T Wack, J Rodin

❮ Previous
Next ❯

Citations

Feb 1, 1993·Journal of Clinical Pharmacology·S K GuptaJ Gorsline
Jan 1, 1995·Psychopharmacology·I P Stolerman, M J Jarvis
Jan 1, 1991·Psychopharmacology·D K HatsukamiJ Hughes
Aug 1, 1995·Psychopharmacology·G SutherlandC Feyerabend
Mar 1, 1995·Psychopharmacology·P WillnerG Eaton
Jan 1, 1992·Psychopharmacology·G SutherlandO Ferno
Jan 1, 1992·Psychopharmacology·D HatsukamiA Callies
Jan 6, 2011·Der Nervenarzt·N VasicZ Sosic-Vasic
Jun 6, 2006·Psychopharmacology·Peter S HendricksThomas H Brandon
Mar 15, 2006·Journal of Behavioral Medicine·Laura J SolomonIra M Bernstein
May 1, 1995·Addictive Behaviors·J GrossM L Stitzer
Nov 1, 2003·Pharmacology, Biochemistry, and Behavior·Jed E RoseAl Salley
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·M L Stitzer, S L Walsh
May 23, 2002·Clinical Therapeutics·Michael J DurcanDavid P L Sachs
Apr 24, 2001·Addictive Behaviors·L M CohenD E McChargue
Jul 5, 2001·Addictive Behaviors·M M WardL M Jack
Mar 14, 1997·Drug and Alcohol Dependence·F G MoellerD R Cherek
Jun 7, 2003·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Shu-Hong ZhuSharon Cummins
May 10, 2000·Psychiatry and Clinical Neurosciences·Y MinoA Babazono
Nov 2, 1995·The New England Journal of Medicine·J E Henningfield
Aug 9, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Marc MooneyDorothy Hatsukami
May 8, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Wasim MaziakThomas Eissenberg
May 23, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jonathan FouldsJohn R Hughes
Nov 1, 1991·British Journal of Addiction·S T Tiffany, D J Drobes
Jul 12, 2008·Journal of Applied Physiology·Alexandre A SteinerAndrej A Romanovsky
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lawrence P CarterDorothy K Hatsukami
May 1, 2010·Therapeutic Advances in Chronic Disease·Giuseppina CasellaRiccardo Polosa
Aug 21, 2008·Anesthesia and Analgesia·Alparslan TuranChristian C Apfel
Dec 15, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth A Myers
Sep 1, 1996·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·C A Patten, J E Martin
Jan 12, 2016·Pharmacology, Biochemistry, and Behavior·Julia K BrynildsenElliot A Stein
Jan 25, 2011·Trends in Pharmacological Sciences·Riccardo Polosa, Neal L Benowitz
Apr 7, 2009·Sleep Medicine Reviews·Andreas JaehneMagdolna Hornyak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of General Psychiatry
J R Hughes, D Hatsukami
European Journal of Clinical Pharmacology
C J JohanssonP O Gunnarsson
© 2022 Meta ULC. All rights reserved