Nicotine reverses the enhanced renal vasodilator capacity in endotoxic rats: Role of α7/α4β2 nAChRs and HSP70

Pharmacological Reports : PR
Abdalla M WednMahmoud M el-Mas

Abstract

Nicotine alleviates renal inflammation and injury induced by endotoxemia. This study investigated (i) the nicotine modulation of hemodynamic and renal vasodilatory responses to endotoxemia in rats, and (ii) roles of α7 or α4β2-nAChRs and related HSP70/TNFα/iNOS signaling in the interaction. Endotoxemia was induced by ip lipopolysaccharide (5 mg/kg/day, for 2 days) and changes in systolic blood pressure and vasodilator responsiveness of isolated perfused kidney to acetylcholine or 5'-N-ethylcarboxamidoadenosine (NECA, adenosine receptor agonist) were evaluated. Lipopolysaccharide had no effect on serum creatinine, reduced blood pressure, and increased renal vasodilations induced by acetylcholine or NECA in male and female preparations. Immunohistochemical analyses showed that lipopolysaccharide reduced renal HSP70 expression, but increased α7-nAChRs, α4β2-nAChRs and iNOS expressions. The co-administration of aminoguanidine (iNOS inhibitor), pentoxifylline (TNFα inhibitor), or nicotine attenuated lipopolysaccharide mediation of renal vasodilations and elevations in α7/α4β2-nAChR and iNOS expressions. Nicotine also reversed the downregulating effect of lipopolysaccharide on HSP70 expression. α7-nAChRs (methyllycaconitine citrate, ...Continue Reading

References

Sep 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K F Badr
Aug 4, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·S J ChenM H Yen
Aug 15, 2000·Experimental Nephrology·S N HeymanM Brezis
Mar 29, 2001·Diabetologia·R SinghL Beilin
Oct 2, 2002·European Journal of Pharmacology·Moez RekikAbdel A Abdel-Rahman
Jul 13, 2004·The New England Journal of Medicine·Robert W Schrier, Wei Wang
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Jean-Jacques Boffa, William J Arendshorst
Jan 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Bunyen TengS Jamal Mustafa
Apr 6, 2005·The Journal of Experimental Medicine·Rubina W SaeedChristine N Metz
May 18, 2005·The Journal of Infectious Diseases·David J van WesterlooTom van der Poll
Jul 6, 2005·Autonomic Neuroscience : Basic & Clinical·Christine Vayssettes-CourchayTony J Verbeuren
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Shigehiko UchinoUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Apr 28, 2006·Kidney International·C LangenbergR Bellomo
Feb 3, 2007·The Journal of Clinical Investigation·Kevin J Tracey
Jun 19, 2007·Intensive Care Medicine·Christoph LangenbergRinaldo Bellomo
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Sean M BagshawUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Apr 11, 2008·Critical Care Medicine·Li WanRinaldo Bellomo
Jul 11, 2008·American Journal of Physiology. Renal Physiology·Michael M YeboahChristine N Metz
Aug 25, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Hans J RoethigPaul E Mendes
Dec 25, 2009·Kidney International·Raghavan MuruganUNKNOWN Genetic and Inflammatory Markers of Sepsis (GenIMS) Investigators
Jan 30, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Peng ZhangGe Zhang
May 10, 2011·Toxicology and Applied Pharmacology·Mahmoud M El-MasEvan I Saad
May 24, 2012·The Journal of Pharmacology and Experimental Therapeutics·Mahmoud M El-MasMai M Helmy
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Mar 8, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrés Ciudad-RobertsElena Escubedo

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.