Nicotine self-administration reverses cognitive deficits in a rat model for schizophrenia

Addiction Biology
Uta WaterhouseBart A Ellenbroek

Abstract

High comorbidity between schizophrenia and tobacco addiction has been well established. Explanatory theories include nicotine as a cognitive enhancer ameliorating symptoms of schizophrenia and underlying shared substrates increasing susceptibility to addiction in these individuals. To test these non-mutually exclusive theories, the maternal immune activation (MIA) model was utilized. To this end, pregnant Sprague Dawley rats were subcutaneously injected with a bacterial endotoxin, lipopolysaccharide (0.5 mg/kg), on gestation days 10 and 11. Selective attention and working memory in adult male offspring were subsequently assessed using the latent inhibition and delayed non-matching to sample paradigms both before and after nicotine or saline self-administration. MIA led to deficits in both latent inhibition and delayed non-matching to sample in male offspring. Further, these animals showed a small but significantly increased responding for nicotine during self-administration acquisition, although there was no difference in dose-response effect or in progressive ratio testing. However, nicotine, but not saline self-administration, significantly ameliorated the cognitive deficits induced by MIA. While the male offspring of mothers...Continue Reading

References

Jan 1, 1989·Psychopharmacology·W A Corrigall, K M Coen
Jan 1, 1995·Psychopharmacology·I P Stolerman, M J Jarvis
Oct 23, 1997·Clinical Microbiology Reviews·J H CurfsJ A Hoogkamp-Korstanje
Mar 22, 2002·Neuron·Huibert D MansvelderDaniel S McGehee
Jan 12, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Jan-Erik Strand, Henrik Nybäck
Jan 8, 2008·Schizophrenia Research·Alasdair M BarrWilliam G Honer
Apr 15, 2008·Schizophrenia Bulletin·Urs MeyerBenjamin K Yee
Aug 12, 2009·Neuroscience and Biobehavioral Reviews·Peter DomeZoltan Rihmer
Feb 4, 2010·The American Journal of Psychiatry·Alan S Brown, Elena J Derkits
Nov 27, 2010·Behavioural Brain Research·Inge KlinkenbergArjan Blokland
Jun 21, 2011·Biochemical Pharmacology·Paul A NewhouseChristiane M Thiel
Nov 30, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Urs Meyer
Jan 17, 2012·Neuropharmacology·Constanze HahnAndres H Neuhaus
Jan 18, 2012·Psychopharmacology·Renata dos Santos Coura, Sylvie Granon
Aug 10, 2013·Biochemical Pharmacology·Edward D Levin
Apr 23, 2014·Addiction Biology·Katharine A BrennanPenelope Truman
Apr 29, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Peter NiemegeersBernard G C Sabbe
Dec 11, 2014·Psychopharmacology·Jason SmucnyJason R Tregellas
Feb 5, 2015·JAMA Psychiatry·Madeleine GoodkindAmit Etkin
Jun 9, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aline R BorçoiRoberto Frussa-Filho
Aug 3, 2016·Disease Models & Mechanisms·Uta WaterhouseBart A Ellenbroek

❮ Previous
Next ❯

Citations

Mar 23, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jillian J WeeksAlan F Sved
May 29, 2019·Current Opinion in Psychiatry·Marina SagudNela Pivac
Oct 28, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Linda ChangJohnny J He
Dec 1, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Suzy Tamie NiigakiVanessa Costhek Abilio

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.