PMID: 11311869Apr 20, 2001Paper

Nicotine sensitization increases dendritic length and spine density in the nucleus accumbens and cingulate cortex

Brain Research
Russell W Brown, B Kolb

Abstract

This study investigated the effects of repeated administrations of nicotine (0.7 mg/kg) on dendritic morphology in the nucleus accumbens (NAcc), prefrontal cortex (Cg 3), and parietal cortex (Par 1). Animals were habituated for 3 days to a locomotor box, and after habituation, every second day for 5 weeks rats were placed into the locomotor chamber immediately after a subcutaneous injection of nicotine or saline. Rats demonstrated tolerance to an initial hypoactive response after each nicotine injection, and this was followed by an increase in activity after each injection (behavioral sensitization). This increase in activity was still present on a nicotine challenge after a 2-week abstinence period. One week after the nicotine challenge day, all rats were perfused and brains were removed. These brains we stained using Golgi-Cox procedures, and dendrites from the nucleus accumbens (N Acc), medial frontal cortex (Cg 3) and parietal cortex (Par 1) were analyzed using the camera lucida procedure. Results showed that rats receiving nicotine demonstrated an increase in dendritic length and spine density relative to controls in the NAcc and Cg3 brain areas, but not Par 1. The increase observed in the NAcc was significantly greater th...Continue Reading

Citations

Oct 18, 2014·Frontiers in Neuroanatomy·Saturnino SpigaMarco Diana
Aug 21, 2003·Journal of Neuroscience Research·R Martínez-RodríguezE De Miguel
Apr 5, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Joseph R DiFranza, Robert J Wellman
Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·R SattaA Guidotti
May 19, 2010·Alcoholism, Clinical and Experimental Research·Traute Flatscher-BaderPeter A Wilce
Jan 1, 2009·Developmental Neurorehabilitation·Celeste HalliwellBryan Kolb
Dec 21, 2018·Journal of Neural Transmission·Marcello SolinasNathalie Thiriet
Aug 4, 2011·PloS One·Zi-Wei ZhangElvire Vaucher
Dec 25, 2016·Psychopharmacology·Jean-Marie N Maddux, Nadia Chaudhri
Mar 15, 2012·Developmental Psychobiology·Bryan Kolb, G Campbell Teskey
Oct 5, 2011·Developmental Medicine and Child Neurology·Bryan KolbRobbin Gibb
Aug 27, 2016·Genes, Brain, and Behavior·C D Gipson, M F Olive
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yilin LiTerry E Robinson
Aug 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bryan KolbTerry E Robinson
Jan 27, 2004·Brain Research. Developmental Brain Research·Robert Riddle, Jonathan D Pollock
Aug 17, 2012·ACS Chemical Neuroscience·Justin T Gass, M Foster Olive
Mar 1, 2019·Molecular Neuropsychiatry·Heath D SchmidtNii A Addy

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