Nicotine withdrawal in adolescent and adult rats

Annals of the New York Academy of Sciences
Laura E O'DellG F Koob

Abstract

Previous research with animal models has demonstrated that adolescent rats display heightened sensitivity to the reinforcing and stimulant effects of nicotine relative to adult rats. Little work has focused on the response of adolescent rats to measures of nicotine withdrawal. To test the hypothesis that adolescent rats may be differentially sensitive to withdrawal relative to their adult counterparts, the present study was designed to compare precipitated withdrawal in adolescent and adult rats following chronic nicotine administration. Adult and adolescent rats were prepared with subcutaneous osmotic minipumps that delivered either saline or nicotine (9 mg/kg per day, salt; N =12 per group). All rats were challenged with the nicotinic receptor antagonist mecamylamine (1.5 mg/kg) on day 7 of chronic nicotine treatment. Twenty minutes after the injection, overt somatic signs of withdrawal (i.e., eye blinks, writhes, body shakes, teeth chatter, gasps, and ptosis) were recorded for 10 min. Adult rats were observed on postnatal day 73-77, and adolescent rats were tested on postnatal day 36-40. The results revealed a robust increase in mecamylamine-induced withdrawal signs in adult rats receiving chronic nicotine relative to adult ...Continue Reading

References

Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·D H MalinO B Wilson
Jan 1, 1991·Archives of General Psychiatry·J R HughesJ W Fenwick
Jun 1, 1990·Trends in Pharmacological Sciences·S Wonnacott
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·X ZhangA Nordberg
Jan 1, 1993·Psychopharmacology·D H MalinO B Wilson
May 1, 1996·Neuron·J A Dani, S Heinemann
Jan 1, 1996·Annual Review of Medicine·J E Rose
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·M M Silveri, L P Spear
May 29, 1999·Critical Reviews in Neurobiology·W J McBride, T K Li
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·S S WatkinsA Markou
Nov 6, 2001·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·A Markou, N E Paterson
May 16, 2002·Neurotoxicology and Teratology·Theodore A Slotkin
Sep 6, 2002·Physiology & Behavior·Bonnie J VastolaLinda P Spear
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Martha M FaradayNeil E Grunberg
May 24, 2003·Psychopharmacology·Edward D LevinH Scott Swartzwelder
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Craig J SlaweckiCindy L Ehlers
Sep 26, 2003·American Journal of Preventive Medicine·Jennifer O'LoughlinGilles Paradis

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Citations

May 21, 2013·Neuropharmacology·Laura E O'Dell, Oscar V Torres
Feb 14, 2006·Psychological Medicine·Monique ErnstMichael Hardin
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hao ChenBurt M Sharp
Nov 13, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kristen R HamiltonNeil E Grunberg
Aug 12, 2008·Behavioural Pharmacology·Marilyn E CarrollNancy K Dess
Jul 30, 2014·Neuroscience and Biobehavioral Reviews·Katharine A BrennanPenelope Truman
Aug 23, 2011·Behavioural Brain Research·Edward D LevinAmir H Rezvani
Oct 30, 2015·Journal of Basic and Clinical Physiology and Pharmacology·Majid MotaghinejadSaeid Ganji
Nov 11, 2009·Hormones and Behavior·Cynthia KuhnQ David Walker
Mar 10, 2009·Pharmacology & Therapeutics·Jennifer B DwyerFrances M Leslie
Jan 6, 2009·Pharmacology, Biochemistry, and Behavior·Laura E O'Dell, Taline V Khroyan
Nov 13, 2008·Pharmacology, Biochemistry, and Behavior·Kristen R HamiltonNeil E Grunberg
Jun 21, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Anne E SmithSuchitra Krishnan-Sarin
Jan 20, 2007·Neurotoxicology and Teratology·Oksana O PolesskayaRobert F Smith
Jul 15, 2004·Annals of the New York Academy of Sciences·Kathleen Ries Merikangas
Mar 23, 2012·Developmental Cognitive Neuroscience·Danielle S CounotteSabine Spijker
Mar 23, 2012·Developmental Cognitive Neuroscience·Graeme Fairchild
Jul 4, 2006·Pharmacology, Biochemistry, and Behavior·Nicole L Schramm-SapytaCynthia M Kuhn
May 3, 2005·European Journal of Pharmacology·Olga D TaraschenkoStanley D Glick
Apr 14, 2016·Neuroscience and Biobehavioral Reviews·Erica Holliday, Thomas J Gould
Jul 26, 2011·Pharmacology, Biochemistry, and Behavior·N S PentkowskiJ L Neisewander
Apr 24, 2012·Neurobiology of Learning and Memory·George S PortugalThomas J Gould
Dec 19, 2006·Pharmacology, Biochemistry, and Behavior·Carrie E Wilmouth, Linda P Spear
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Erica D Holliday, Thomas J Gould
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Tamara L Doremus-Fitzwater, Linda P Spear
Oct 26, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·June Bryan de la PeñaJae Hoon Cheong

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