Nicotine withdrawal increases stress-associated genes in the nucleus accumbens of female rats in a hormone-dependent manner

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Oscar V TorresLaura E O'Dell

Abstract

Previous work led to our hypothesis that sex differences produced by nicotine withdrawal are modulated by stress and dopamine systems in the nucleus accumbens (NAcc). We investigated our hypothesis by studying intact females to determine whether the mechanisms that promote withdrawal are ovarian-hormone mediated. Female rats were ovariectomized (OVX) or received sham surgery (intact) on postnatal day (PND 45-46). On PND 60, they received sham surgery (controls) or were prepared with nicotine pumps. Fourteen days later, half of the rats had their pumps removed (nicotine withdrawal) and the other half received sham surgery (nicotine exposure). Twenty-four hours later, the rats were tested for anxiety-like behavior using the elevated plus maze and light/dark transfer procedures. The NAcc was then dissected for analysis of several genes related to stress (CRF, UCN, CRF-R1, CRF-R2, CRF-BP, and Arrb2) or receptors for dopamine (Drd1 and Drd2) and estradiol (Esr2). During withdrawal, intact females displayed an increase in anxiety-like behavior in both tests and CRF, UCN, and Drd1 gene expression. During nicotine exposure, intact females displayed a decrease in CRF-R1, CRF-R2, Drd3, and Esr2 gene expression and an increase in CRF-BP. ...Continue Reading

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Citations

Apr 29, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Oscar V Torres, Laura E O'Dell
Apr 10, 2016·Behavioural Brain Research·Rodolfo J FloresLaura E O'Dell
Jul 28, 2016·Frontiers in Neuroendocrinology·P Barra de la Tremblaye, H Plamondon
Oct 16, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin P UribeLaura E O'Dell
Nov 22, 2016·Journal of Neuroscience Research·Aimee L McRae-ClarkKathleen T Brady
Nov 22, 2016·Journal of Neuroscience Research·Sakire PogunLutfiye Kanit
Nov 22, 2016·Journal of Neuroscience Research·Sarah J CrossFrances M Leslie
Apr 25, 2020·Brain Research·Sierra SimpsonOlivier George
Apr 24, 2021·Journal of Psychopharmacology·Ranjithkumar ChellianAdriaan W Bruijnzeel

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