Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders

Behavioural Brain Research
Samantha L McLeanJo C Neill

Abstract

Cholinergic dysfunction has been shown to be central to the pathophysiology of Alzheimer's disease and has also been postulated to contribute to cognitive dysfunction observed in various psychiatric disorders, including schizophrenia. Deficits are found across a number of cognitive domains and in spite of several attempts to develop new therapies, these remain an unmet clinical need. In the current study we investigated the efficacy of donepezil, risperidone and selective nicotinic α7 and α4β2 receptor agonists to reverse a delay-induced deficit in recognition memory. Adult female Hooded Lister rats received drug treatments and were tested in the novel object recognition (NOR) task following a 6h inter-trial interval (ITI). In all treatment groups, there was no preference for the left or right identical objects in the acquisition trial. Risperidone failed to enhance recognition memory in this paradigm whereas donepezil was effective such that rats discriminated between the novel and familiar object in the retention trial following a 6h ITI. Although a narrow dose range of PNU-282987 and RJR-2403 was tested, only one dose of each increased recognition memory, the highest dose of PNU-282987 (10mg/kg) and the lowest dose of RJR-24...Continue Reading

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Apr 12, 2016·Chemico-biological Interactions·Natalia N Nalivaeva, Anthony J Turner
Feb 6, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andrew HaywardJoanna C Neill
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Jun 1, 2018·Neural Plasticity·Vladimir S Naumenko, Evgeni Ponimaskin
Jun 28, 2020·BMC Neuroscience·Young-Sung KimIl Ok Lee
Aug 22, 2021·Behavioural Pharmacology·Gail Winger

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